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Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

The ability to alter antigen specificity by T-cell receptor (TCR) or chimeric antigen receptor (CAR) gene transfer has facilitated personalized cellular immune therapies in cancer. Inversely, this approach can be harnessed in autoimmune settings to attenuate inflammation by redirecting the specifici...

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Detalles Bibliográficos
Autores principales:	Yeh, Wen-I, Seay, Howard R., Newby, Brittney, Posgai, Amanda L., Moniz, Filipa Botelho, Michels, Aaron, Mathews, Clayton E., Bluestone, Jeffrey A., Brusko, Todd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662552/ https://www.ncbi.nlm.nih.gov/pubmed/29123516 http://dx.doi.org/10.3389/fimmu.2017.01313

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