Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

Myoepithelial carcinoma (MECA) is an aggressive salivary gland cancer with largely unknown genetic features. Here we comprehensively analyze molecular alterations in 40 MECAs using integrated genomic analyses. We identify a low mutational load, and high prevalence (70%) of oncogenic gene fusions. Mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Dalin, Martin G., Katabi, Nora, Persson, Marta, Lee, Ken-Wing, Makarov, Vladimir, Desrichard, Alexis, Walsh, Logan A., West, Lyndsay, Nadeem, Zaineb, Ramaswami, Deepa, Havel, Jonathan J., Kuo, Fengshen, Chadalavada, Kalyani, Nanjangud, Gouri J., Ganly, Ian, Riaz, Nadeem, Ho, Alan L., Antonescu, Cristina R., Ghossein, Ronald, Stenman, Göran, Chan, Timothy A., Morris, Luc G. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662567/
https://www.ncbi.nlm.nih.gov/pubmed/29084941
http://dx.doi.org/10.1038/s41467-017-01178-z

Ejemplares similares

Ejemplares similares