Leishmania infantum lipophosphoglycan induced-Prostaglandin E(2) production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2

Lipophosphoglycan (LPG) is a key virulence factor expressed on the surfaces of Leishmania promastigotes. Although LPG is known to activate macrophages, the underlying mechanisms resulting in the production of prostaglandin E(2) (PGE(2)) via signaling pathways remain unknown. Here, the inflammatory r...

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Detalles Bibliográficos
Autores principales: Lima, Jonilson Berlink, Araújo-Santos, Théo, Lázaro-Souza, Milena, Carneiro, Alan Brito, Ibraim, Izabela Coimbra, Jesus-Santos, Flávio Henrique, Luz, Nívea Farias, Pontes, Sara de Moura, Entringer, Petter Franco, Descoteaux, Albert, Bozza, Patrícia Torres, Soares, Rodrigo Pedro, Borges, Valéria Matos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662570/
https://www.ncbi.nlm.nih.gov/pubmed/29084985
http://dx.doi.org/10.1038/s41598-017-14229-8

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