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Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly
Starvation reduces sleep in various animal species including humans and fruit flies. Immediate hunger and the following insufficient nutritional status resulting from starvation may affect sleep and arousal differently. In order to clarify the mechanism underlying the relationship between diet and s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662574/ https://www.ncbi.nlm.nih.gov/pubmed/29084998 http://dx.doi.org/10.1038/s41598-017-14608-1 |
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author | Hasegawa, Tatsuya Tomita, Jun Hashimoto, Rina Ueno, Taro Kume, Shoen Kume, Kazuhiko |
author_facet | Hasegawa, Tatsuya Tomita, Jun Hashimoto, Rina Ueno, Taro Kume, Shoen Kume, Kazuhiko |
author_sort | Hasegawa, Tatsuya |
collection | PubMed |
description | Starvation reduces sleep in various animal species including humans and fruit flies. Immediate hunger and the following insufficient nutritional status resulting from starvation may affect sleep and arousal differently. In order to clarify the mechanism underlying the relationship between diet and sleep, we analysed the sleep behaviour of Drosophila melanogaster that were either starved or fed with different types of sugars. Starved flies showed longer activity bouts, short sleep bouts and a decreased arousal threshold. Non-nutritive sweeteners such as sucralose and arabinose, which are sweet but not nutritive, induced sleep in starved flies, but sleep bout length and the arousal threshold was short and decreased, respectively. On the other hand, sorbitol, which is not sweet but nutritive, did not induce sleep, but slightly increased the lowered arousal threshold. Activation of sweetness receptor expressing neurons induced sleep in starved flies. These results suggest that sweetness alone is sufficient to induce sleep in starved flies and that the nutritional status affects sleep homeostasis by decreasing the arousal threshold, which resulted in short sleep bouts in Drosophila. |
format | Online Article Text |
id | pubmed-5662574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56625742017-11-08 Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly Hasegawa, Tatsuya Tomita, Jun Hashimoto, Rina Ueno, Taro Kume, Shoen Kume, Kazuhiko Sci Rep Article Starvation reduces sleep in various animal species including humans and fruit flies. Immediate hunger and the following insufficient nutritional status resulting from starvation may affect sleep and arousal differently. In order to clarify the mechanism underlying the relationship between diet and sleep, we analysed the sleep behaviour of Drosophila melanogaster that were either starved or fed with different types of sugars. Starved flies showed longer activity bouts, short sleep bouts and a decreased arousal threshold. Non-nutritive sweeteners such as sucralose and arabinose, which are sweet but not nutritive, induced sleep in starved flies, but sleep bout length and the arousal threshold was short and decreased, respectively. On the other hand, sorbitol, which is not sweet but nutritive, did not induce sleep, but slightly increased the lowered arousal threshold. Activation of sweetness receptor expressing neurons induced sleep in starved flies. These results suggest that sweetness alone is sufficient to induce sleep in starved flies and that the nutritional status affects sleep homeostasis by decreasing the arousal threshold, which resulted in short sleep bouts in Drosophila. Nature Publishing Group UK 2017-10-30 /pmc/articles/PMC5662574/ /pubmed/29084998 http://dx.doi.org/10.1038/s41598-017-14608-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hasegawa, Tatsuya Tomita, Jun Hashimoto, Rina Ueno, Taro Kume, Shoen Kume, Kazuhiko Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
title | Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
title_full | Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
title_fullStr | Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
title_full_unstemmed | Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
title_short | Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
title_sort | sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662574/ https://www.ncbi.nlm.nih.gov/pubmed/29084998 http://dx.doi.org/10.1038/s41598-017-14608-1 |
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