In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer. Beyond the canonical biosynthetic routes to produce biomass, it is of key importance to focus on metabolic routes that sustain the proliferative ca...

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Detalles Bibliográficos
Autores principales: Pey, Jon, San José-Eneriz, Edurne, Ochoa, María Carmen, Apaolaza, Iñigo, de Atauri, Pedro, Rubio, Angel, Cendoya, Xabier, Miranda, Estíbaliz, Garate, Leire, Cascante, Marta, Carracedo, Arkaitz, Agirre, Xabier, Prosper, Felipe, Planes, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662602/
https://www.ncbi.nlm.nih.gov/pubmed/29084986
http://dx.doi.org/10.1038/s41598-017-14067-8

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