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Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD

Bacterial ABC importers catalyze the uptake of essential nutrients including transition metals and metal-containing co-factors. Recently, an IgG antibody targeting the external binding protein of the Staphylococcus aureus Mn(II) ABC importer was reported to inhibit transport activity and reduce bact...

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Detalles Bibliográficos
Autores principales:	Mireku, S. A., Sauer, M. M., Glockshuber, R., Locher, K. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662663/ https://www.ncbi.nlm.nih.gov/pubmed/29084999 http://dx.doi.org/10.1038/s41598-017-14512-8

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