Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

There is a growing body of evidence about the presence and the activity of the miRISC in the nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 interacts with the nucleoplasmic protein Sfpq in an RNA-dependent fashion. By a combination of HITS-CLIP and transcripto...

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Detalles Bibliográficos
Autores principales: Bottini, Silvia, Hamouda-Tekaya, Nedra, Mategot, Raphael, Zaragosi, Laure-Emmanuelle, Audebert, Stephane, Pisano, Sabrina, Grandjean, Valerie, Mauduit, Claire, Benahmed, Mohamed, Barbry, Pascal, Repetto, Emanuela, Trabucchi, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662751/
https://www.ncbi.nlm.nih.gov/pubmed/29084942
http://dx.doi.org/10.1038/s41467-017-01126-x

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