Cargando…

Identify a Blood-Brain Barrier Penetrating Drug-TNB using Zebrafish Orthotopic Glioblastoma Xenograft Model

The blood–brain barrier (BBB) is necessary for maintaining brain homeostasis, but it also represents a major challenge for drug delivery to the brain tumors. A suitable in vivo Glioblastoma Multiforme (GBM) model is needed for efficient testing of BBB crossable pharmaceuticals. In this study, we fir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Anqi, Ye, Tinghong, Cao, Dan, Huang, Xi, Yang, Yu, Chen, Xiuli, Xie, Yongmei, Yao, Shaohua, Zhao, Chengjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662771/ https://www.ncbi.nlm.nih.gov/pubmed/29085081 http://dx.doi.org/10.1038/s41598-017-14766-2

Ejemplares similares

Clinically relevant orthotopic xenograft models of patient-derived glioblastoma in zebrafish
por: Ai, Xiaolin, et al.
Publicado: (2022)

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts
por: Koessinger, Anna L., et al.
Publicado: (2020)

Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy
por: Patrizii, Michele, et al.
Publicado: (2018)

Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts
por: Pacioni, Simone, et al.
Publicado: (2017)

Generation of glioblastoma patient-derived organoids and mouse brain orthotopic xenografts for drug screening
por: Gamboa, Christian Moya, et al.
Publicado: (2021)

Ex vivo efficacy of BCMA‐bispecific antibody TNB‐383B in relapsed/refractory multiple myeloma
por: Foureau, David M., et al.
Publicado: (2020)

Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity
por: Welker, Alessandra M., et al.
Publicado: (2016)

Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma
por: Shankavaram, Uma T, et al.
Publicado: (2012)

Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts
por: Coutinho de Souza, Patricia, et al.
Publicado: (2015)

Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery
por: Thisgaard, Helge, et al.
Publicado: (2016)

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice
por: Cudalbu, Cristina, et al.
Publicado: (2021)

Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models
por: Gherardini, Lisa, et al.
Publicado: (2023)

Loss of heterozygosity related to TMB and TNB may predict PFS for patients with SCLC received the first line setting
por: Zhang, Chenyue, et al.
Publicado: (2021)

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
por: Ugamraj, Harshad S., et al.
Publicado: (2022)

Real-time evaluation of glioblastoma growth in patient-specific zebrafish xenografts
por: Almstedt, Elin, et al.
Publicado: (2021)

Correction: Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity
por: Welker, Alessandra M., et al.
Publicado: (2016)

Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model
por: Chen, Quanchi, et al.
Publicado: (2022)

Zebrafish functional xenograft vasculature platform identifies PF-502 as a durable vasculature normalization drug
por: Zhong, Jian, et al.
Publicado: (2023)

Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma
por: Zhang, Dongya, et al.
Publicado: (2022)

Imaging of Orthotopic Glioblastoma Xenografts in Mice Using a Clinical CT Scanner: Comparison with Micro-CT and Histology
por: Kirschner, Stefanie, et al.
Publicado: (2016)

Communicating hydrocephalus associated to ventral leptomeningeal invasion leads to precocious death in a glioblastoma orthotopic xenograft model
por: Lombard, Arnaud, et al.
Publicado: (2020)

TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL
por: Malik-Chaudhry, Harbani K., et al.
Publicado: (2021)

Experimental orthotopic penetrating keratoplasty--a rat penetrating keratoplasty model.
por: Tchah, H., et al.
Publicado: (1991)

Development of clinically relevant orthotopic xenograft mouse model of metastatic lung cancer and glioblastoma through surgical tumor tissues injection with trocar
por: Fei, Xi Feng, et al.
Publicado: (2010)

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
por: Jäger, Wolfgang, et al.
Publicado: (2014)

Development and characterization of a human orthotopic neuroblastoma xenograft
por: Stewart, Elizabeth, et al.
Publicado: (2015)

Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors
por: Stewart, Elizabeth, et al.
Publicado: (2017)

Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma †
por: Hoffman, Robert M.
Publicado: (2017)

Orthotopic tumours, a hot topic for xenograft models?
por: Zheng, Dali
Publicado: (2019)

A Novel Xenograft Model in Zebrafish for High-Resolution Investigating Dynamics of Neovascularization in Tumors
por: Zhao, Chengjian, et al.
Publicado: (2011)

EGFR Gene Overexpression Retained in an Invasive Xenograft Model by Solid Orthotopic Transplantation of Human Glioblastoma Multiforme Into Nude Mice
por: Yi, Diao, et al.
Publicado: (2011)

Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model
por: Crommentuijn, Matheus HW, et al.
Publicado: (2016)

Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts
por: Takahashi, Masamichi, et al.
Publicado: (2019)

The Use of Longitudinal (18)F-FET MicroPET Imaging to Evaluate Response to Irinotecan in Orthotopic Human Glioblastoma Multiforme Xenografts
por: Nedergaard, Mette K., et al.
Publicado: (2014)

Intracranial AAV‐IFN‐β gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model
por: GuhaSarkar, Dwijit, et al.
Publicado: (2017)

IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts
por: Kurbegovic, Sorel, et al.
Publicado: (2021)

Transthoracic Needle Biopsy (TNB) under Different Guiding Methods - the Experience of the Thoracic Surgery Clinic of Craiova after the First 235 Cases
por: DEMETRIAN, A., et al.
Publicado: (2015)

An orthotopic xenograft model of human nonseminomatous germ cell tumour
por: Douglas, M L, et al.
Publicado: (2001)

Dynamic Quantitative T1 Mapping in Orthotopic Brain Tumor Xenografts()
por: Herrmann, Kelsey, et al.
Publicado: (2016)

Circadian rhythm characteristics of oral squamous cell carcinoma growth in an orthotopic xenograft model
por: Zhao, Ningbo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_t366fmtpebg59h6mqrb3s6ag9a