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IL-17A-Producing Foxp3(+) Regulatory T Cells and Human Diseases
CD4(+)Foxp3(+) regulatory T (Treg) cells play major roles in immune homeostasis. While CD4(+)Foxp3(+) Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Immunologists
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662777/ https://www.ncbi.nlm.nih.gov/pubmed/29093649 http://dx.doi.org/10.4110/in.2017.17.5.276 |
Sumario: | CD4(+)Foxp3(+) regulatory T (Treg) cells play major roles in immune homeostasis. While CD4(+)Foxp3(+) Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4(+)Foxp3(+) Treg cells. In particular, IL-17A-producing CD4(+)Foxp3(+) Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3. IL-17A-producing CD4(+)Foxp3(+) Treg cells are also involved in the pathogenesis of various diseases. Here we review the mechanisms underlying the induction of IL-17A-producing CD4(+)Foxp3(+) Treg cells and the roles of these cells in human disease. |
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