A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics

Single antimicrobial therapy has been unable to resist the global spread of bacterial resistance. Literatures of available in vitro and in vivo studies were reviewed and the results showed that low frequency ultrasound (LFU) has a promising synergistic bactericidal effect with antibiotics against bo...

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Detalles Bibliográficos
Autores principales: Cai, Yun, Wang, Jin, Liu, Xu, Wang, Rui, Xia, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662814/
https://www.ncbi.nlm.nih.gov/pubmed/29124063
http://dx.doi.org/10.1155/2017/2317846
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author Cai, Yun
Wang, Jin
Liu, Xu
Wang, Rui
Xia, Lei
author_facet Cai, Yun
Wang, Jin
Liu, Xu
Wang, Rui
Xia, Lei
author_sort Cai, Yun
collection PubMed
description Single antimicrobial therapy has been unable to resist the global spread of bacterial resistance. Literatures of available in vitro and in vivo studies were reviewed and the results showed that low frequency ultrasound (LFU) has a promising synergistic bactericidal effect with antibiotics against both planktonic and biofilm bacteria. It also can facilitate the release of antibiotics from medical implants. As a noninvasive and targeted therapy, LFU has great potential in treating bacterial infections. However, more in-depth and detailed studies are still needed before LFU is officially applied as a combination therapy in the field of anti-infective treatment.
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spelling pubmed-56628142017-11-09 A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics Cai, Yun Wang, Jin Liu, Xu Wang, Rui Xia, Lei Biomed Res Int Review Article Single antimicrobial therapy has been unable to resist the global spread of bacterial resistance. Literatures of available in vitro and in vivo studies were reviewed and the results showed that low frequency ultrasound (LFU) has a promising synergistic bactericidal effect with antibiotics against both planktonic and biofilm bacteria. It also can facilitate the release of antibiotics from medical implants. As a noninvasive and targeted therapy, LFU has great potential in treating bacterial infections. However, more in-depth and detailed studies are still needed before LFU is officially applied as a combination therapy in the field of anti-infective treatment. Hindawi 2017 2017-10-16 /pmc/articles/PMC5662814/ /pubmed/29124063 http://dx.doi.org/10.1155/2017/2317846 Text en Copyright © 2017 Yun Cai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cai, Yun
Wang, Jin
Liu, Xu
Wang, Rui
Xia, Lei
A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
title A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
title_full A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
title_fullStr A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
title_full_unstemmed A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
title_short A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
title_sort review of the combination therapy of low frequency ultrasound with antibiotics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662814/
https://www.ncbi.nlm.nih.gov/pubmed/29124063
http://dx.doi.org/10.1155/2017/2317846
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