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Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans

Paired associative stimulation (PAS) produces enduring neuroplasticity based on Hebbian associative plasticity. This study established the changes in spinal motoneuronal excitability by pairing transcortical and transspinal stimulation. Transcortical stimulation was delivered after (transspinal-tran...

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Autor principal: Knikou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662837/
https://www.ncbi.nlm.nih.gov/pubmed/29123926
http://dx.doi.org/10.1155/2017/6751810
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author Knikou, Maria
author_facet Knikou, Maria
author_sort Knikou, Maria
collection PubMed
description Paired associative stimulation (PAS) produces enduring neuroplasticity based on Hebbian associative plasticity. This study established the changes in spinal motoneuronal excitability by pairing transcortical and transspinal stimulation. Transcortical stimulation was delivered after (transspinal-transcortical PAS) or before (transcortical-transspinal PAS) transspinal stimulation. Before and after 40 minutes of each PAS protocol, spinal neural excitability was assessed based on the amplitude of the transspinal-evoked potentials (TEPs) recorded from ankle muscles of both legs at different stimulation intensities (recruitment input-output curve). Changes in TEPs amplitude in response to low-frequency stimulation and paired transspinal stimuli were also established before and after each PAS protocol. TEP recruitment input-output curves revealed a generalized depression of TEPs in most ankle muscles of both legs after both PAS protocols that coincided with an increased gain only after transcortical-transspinal PAS. Transcortical-transspinal PAS increased and transspinal-transcortical PAS decreased the low-frequency-dependent TEP depression, whereas neither PAS protocol affected the TEP depression observed upon paired transspinal stimuli. These findings support the notion that transspinal and transcortical PAS has the ability to alter concomitantly cortical and spinal synaptic activity. Transspinal and transcortical PAS may contribute to the development of rehabilitation strategies in people with bilateral increased motoneuronal excitability due to cortical or spinal lesions.
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spelling pubmed-56628372017-11-09 Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans Knikou, Maria Neural Plast Research Article Paired associative stimulation (PAS) produces enduring neuroplasticity based on Hebbian associative plasticity. This study established the changes in spinal motoneuronal excitability by pairing transcortical and transspinal stimulation. Transcortical stimulation was delivered after (transspinal-transcortical PAS) or before (transcortical-transspinal PAS) transspinal stimulation. Before and after 40 minutes of each PAS protocol, spinal neural excitability was assessed based on the amplitude of the transspinal-evoked potentials (TEPs) recorded from ankle muscles of both legs at different stimulation intensities (recruitment input-output curve). Changes in TEPs amplitude in response to low-frequency stimulation and paired transspinal stimuli were also established before and after each PAS protocol. TEP recruitment input-output curves revealed a generalized depression of TEPs in most ankle muscles of both legs after both PAS protocols that coincided with an increased gain only after transcortical-transspinal PAS. Transcortical-transspinal PAS increased and transspinal-transcortical PAS decreased the low-frequency-dependent TEP depression, whereas neither PAS protocol affected the TEP depression observed upon paired transspinal stimuli. These findings support the notion that transspinal and transcortical PAS has the ability to alter concomitantly cortical and spinal synaptic activity. Transspinal and transcortical PAS may contribute to the development of rehabilitation strategies in people with bilateral increased motoneuronal excitability due to cortical or spinal lesions. Hindawi 2017 2017-10-16 /pmc/articles/PMC5662837/ /pubmed/29123926 http://dx.doi.org/10.1155/2017/6751810 Text en Copyright © 2017 Maria Knikou. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Knikou, Maria
Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans
title Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans
title_full Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans
title_fullStr Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans
title_full_unstemmed Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans
title_short Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans
title_sort spinal excitability changes after transspinal and transcortical paired associative stimulation in humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662837/
https://www.ncbi.nlm.nih.gov/pubmed/29123926
http://dx.doi.org/10.1155/2017/6751810
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