Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers

Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because...

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Detalles Bibliográficos
Autores principales: Stefan, Christopher J., Trimble, William S., Grinstein, Sergio, Drin, Guillaume, Reinisch, Karin, De Camilli, Pietro, Cohen, Sarah, Valm, Alex M., Lippincott-Schwartz, Jennifer, Levine, Tim P., Iaea, David B., Maxfield, Frederick R., Futter, Clare E., Eden, Emily R., Judith, Delphine, van Vliet, Alexander R., Agostinis, Patrizia, Tooze, Sharon A., Sugiura, Ayumu, McBride, Heidi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663033/
https://www.ncbi.nlm.nih.gov/pubmed/29089042
http://dx.doi.org/10.1186/s12915-017-0432-0
Descripción
Sumario:Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.

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