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The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

BACKGROUND: Most eukaryotic genes are subject to alternative splicing (AS), which may contribute to the production of protein variants or to the regulation of gene expression via nonsense-mediated messenger RNA (mRNA) decay (NMD). However, a fraction of splice variants might correspond to spurious t...

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Detalles Bibliográficos
Autores principales:	Saudemont, Baptiste, Popa, Alexandra, Parmley, Joanna L., Rocher, Vincent, Blugeon, Corinne, Necsulea, Anamaria, Meyer, Eric, Duret, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663052/ https://www.ncbi.nlm.nih.gov/pubmed/29084568 http://dx.doi.org/10.1186/s13059-017-1344-6

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