A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure

Dual antiplatelet agents and high-intensity statins are frequently used in combination after myocardial infarction. Ticagrelor has the potential of causing acute kidney injury. Rosuvastatin is excreted through the kidneys and dose adjustment is needed in patients with kidney disease. When used in co...

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Autores principales: Samuel, Gbeminiyi, Atanda, Adebayo C, Onyemeh, Alex, Awan, Ahmad, Ajiboye, Oyintayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Nephrology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663323/
https://www.ncbi.nlm.nih.gov/pubmed/29104841
http://dx.doi.org/10.7759/cureus.1633
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author Samuel, Gbeminiyi
Atanda, Adebayo C
Onyemeh, Alex
Awan, Ahmad
Ajiboye, Oyintayo
author_facet Samuel, Gbeminiyi
Atanda, Adebayo C
Onyemeh, Alex
Awan, Ahmad
Ajiboye, Oyintayo
author_sort Samuel, Gbeminiyi
collection PubMed
description Dual antiplatelet agents and high-intensity statins are frequently used in combination after myocardial infarction. Ticagrelor has the potential of causing acute kidney injury. Rosuvastatin is excreted through the kidneys and dose adjustment is needed in patients with kidney disease. When used in combination, they can potentiate the toxic effects of each other. We report a case of drug interaction between rosuvastatin and ticagrelor resulting in rhabdomyolysis and acute renal failure necessitating dialysis. This case stresses the importance of monitoring renal function and adjusting the dose of rosuvastatin accordingly in patients with kidney disease.
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spelling pubmed-56633232017-11-04 A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure Samuel, Gbeminiyi Atanda, Adebayo C Onyemeh, Alex Awan, Ahmad Ajiboye, Oyintayo Cureus Nephrology Dual antiplatelet agents and high-intensity statins are frequently used in combination after myocardial infarction. Ticagrelor has the potential of causing acute kidney injury. Rosuvastatin is excreted through the kidneys and dose adjustment is needed in patients with kidney disease. When used in combination, they can potentiate the toxic effects of each other. We report a case of drug interaction between rosuvastatin and ticagrelor resulting in rhabdomyolysis and acute renal failure necessitating dialysis. This case stresses the importance of monitoring renal function and adjusting the dose of rosuvastatin accordingly in patients with kidney disease. Cureus 2017-08-31 /pmc/articles/PMC5663323/ /pubmed/29104841 http://dx.doi.org/10.7759/cureus.1633 Text en Copyright © 2017, Samuel et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Nephrology
Samuel, Gbeminiyi
Atanda, Adebayo C
Onyemeh, Alex
Awan, Ahmad
Ajiboye, Oyintayo
A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
title A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
title_full A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
title_fullStr A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
title_full_unstemmed A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
title_short A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
title_sort unique case of drug interaction between ticagrelor and statin leading to acute renal failure
topic Nephrology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663323/
https://www.ncbi.nlm.nih.gov/pubmed/29104841
http://dx.doi.org/10.7759/cureus.1633
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