Cargando…

Development of an interstitial cystitis risk score for bladder permeability

BACKGROUND: Interstitial cystitis/bladder pain syndrome (IC) is a multifactorial syndrome of severe pelvic and genitalia pain and compromised urinary function; a subset of IC patients present with Hunner’s lesions or ulcers on their bladder walls (UIC). UIC is diagnosed by cystoscopy, which may be q...

Descripción completa

Detalles Bibliográficos
Autores principales: Lamb, Laura E., Janicki, Joseph J., Bartolone, Sarah N., Peters, Kenneth M., Chancellor, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663335/
https://www.ncbi.nlm.nih.gov/pubmed/29088231
http://dx.doi.org/10.1371/journal.pone.0185686
_version_ 1783274797616070656
author Lamb, Laura E.
Janicki, Joseph J.
Bartolone, Sarah N.
Peters, Kenneth M.
Chancellor, Michael B.
author_facet Lamb, Laura E.
Janicki, Joseph J.
Bartolone, Sarah N.
Peters, Kenneth M.
Chancellor, Michael B.
author_sort Lamb, Laura E.
collection PubMed
description BACKGROUND: Interstitial cystitis/bladder pain syndrome (IC) is a multifactorial syndrome of severe pelvic and genitalia pain and compromised urinary function; a subset of IC patients present with Hunner’s lesions or ulcers on their bladder walls (UIC). UIC is diagnosed by cystoscopy, which may be quite painful. The objective of this study was to determine if a calculated Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines could discriminate UIC patients from controls and IC patients without Hunner’s ulcers. METHODS: A national crowdsourcing effort targeted IC patients and age-matched controls to provide urine samples. Urinary cytokine levels for GRO, IL-6, and IL-8 were determined using a Luminex assay. RESULTS: We collected 448 urine samples from 46 states consisting of 153 IC patients (147 female, 6 male), of which 54 UIC patients (50 females, 4 male), 159 female controls, and 136 male controls. A defined BP-RS was calculated to classify UIC, or a bladder permeability defect etiology, with 89% validity. CONCLUSIONS: The BP-RS Score quantifies UIC risk, indicative of a bladder permeability defect etiology in a subset of IC patients. The Bladder Permeability Defect Risk Score is the first validated urine biomarker assay for interstitial cystitis/bladder pain syndrome.
format Online
Article
Text
id pubmed-5663335
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-56633352017-11-09 Development of an interstitial cystitis risk score for bladder permeability Lamb, Laura E. Janicki, Joseph J. Bartolone, Sarah N. Peters, Kenneth M. Chancellor, Michael B. PLoS One Research Article BACKGROUND: Interstitial cystitis/bladder pain syndrome (IC) is a multifactorial syndrome of severe pelvic and genitalia pain and compromised urinary function; a subset of IC patients present with Hunner’s lesions or ulcers on their bladder walls (UIC). UIC is diagnosed by cystoscopy, which may be quite painful. The objective of this study was to determine if a calculated Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines could discriminate UIC patients from controls and IC patients without Hunner’s ulcers. METHODS: A national crowdsourcing effort targeted IC patients and age-matched controls to provide urine samples. Urinary cytokine levels for GRO, IL-6, and IL-8 were determined using a Luminex assay. RESULTS: We collected 448 urine samples from 46 states consisting of 153 IC patients (147 female, 6 male), of which 54 UIC patients (50 females, 4 male), 159 female controls, and 136 male controls. A defined BP-RS was calculated to classify UIC, or a bladder permeability defect etiology, with 89% validity. CONCLUSIONS: The BP-RS Score quantifies UIC risk, indicative of a bladder permeability defect etiology in a subset of IC patients. The Bladder Permeability Defect Risk Score is the first validated urine biomarker assay for interstitial cystitis/bladder pain syndrome. Public Library of Science 2017-10-31 /pmc/articles/PMC5663335/ /pubmed/29088231 http://dx.doi.org/10.1371/journal.pone.0185686 Text en © 2017 Lamb et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lamb, Laura E.
Janicki, Joseph J.
Bartolone, Sarah N.
Peters, Kenneth M.
Chancellor, Michael B.
Development of an interstitial cystitis risk score for bladder permeability
title Development of an interstitial cystitis risk score for bladder permeability
title_full Development of an interstitial cystitis risk score for bladder permeability
title_fullStr Development of an interstitial cystitis risk score for bladder permeability
title_full_unstemmed Development of an interstitial cystitis risk score for bladder permeability
title_short Development of an interstitial cystitis risk score for bladder permeability
title_sort development of an interstitial cystitis risk score for bladder permeability
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663335/
https://www.ncbi.nlm.nih.gov/pubmed/29088231
http://dx.doi.org/10.1371/journal.pone.0185686
work_keys_str_mv AT lamblaurae developmentofaninterstitialcystitisriskscoreforbladderpermeability
AT janickijosephj developmentofaninterstitialcystitisriskscoreforbladderpermeability
AT bartolonesarahn developmentofaninterstitialcystitisriskscoreforbladderpermeability
AT peterskennethm developmentofaninterstitialcystitisriskscoreforbladderpermeability
AT chancellormichaelb developmentofaninterstitialcystitisriskscoreforbladderpermeability