Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements

[Image: see text] Efforts to develop inhibitors, activators, and effectors of biological reactions using small molecule libraries are often hampered by interference compounds, artifacts, and false positives that permeate the pool of initial hits. Here, we report the discovery of a promising initial...

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Detalles Bibliográficos
Autores principales: Morreale, Francesca E., Testa, Andrea, Chaugule, Viduth K., Bortoluzzi, Alessio, Ciulli, Alessio, Walden, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663392/
https://www.ncbi.nlm.nih.gov/pubmed/28933844
http://dx.doi.org/10.1021/acs.jmedchem.7b01071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663392/
https://www.ncbi.nlm.nih.gov/pubmed/28933844
http://dx.doi.org/10.1021/acs.jmedchem.7b01071

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