Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction

Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. Causative mutations in several genes associated with the sonic hedgehog (SHH) signaling pathway, including PTCH1, have be...

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Detalles Bibliográficos
Autores principales: Hasegawa, Daigo, Ochiai-Shino, Hiromi, Onodera, Shoko, Nakamura, Takashi, Saito, Akiko, Onda, Takeshi, Watanabe, Katsuhito, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Kosaki, Kenjiro, Yamaguchi, Akira, Shibahara, Takahiko, Azuma, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663396/
https://www.ncbi.nlm.nih.gov/pubmed/29088246
http://dx.doi.org/10.1371/journal.pone.0186879

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