Free energy landscape of siRNA-polycation complexation: Elucidating the effect of molecular geometry, polymer flexibility, and charge neutralization

The success of medical threatments with DNA and silencing interference RNA is strongly related to the design of efficient delivery technologies. Cationic polymers represent an attractive strategy to serve as nucleic-acid carriers with the envisioned advantages of efficient complexation, low cost, ea...

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Detalles Bibliográficos
Autores principales: Grasso, Gianvito, Deriu, Marco Agostino, Patrulea, Viorica, Borchard, Gerrit, Möller, Michael, Danani, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663398/
https://www.ncbi.nlm.nih.gov/pubmed/29088239
http://dx.doi.org/10.1371/journal.pone.0186816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663398/
https://www.ncbi.nlm.nih.gov/pubmed/29088239
http://dx.doi.org/10.1371/journal.pone.0186816

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