Cargando…

Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia

The genetic heterogeneity of acute myeloid leukemia (AML) and the variable responses of individual patients to therapy suggest that different AML genotypes may influence the bone marrow (BM) microenvironment in different ways. We performed gene expression profiling of bone marrow mesenchymal stromal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jacamo, Rodrigo, Davis, R. Eric, Ling, Xiaoyang, Sonnylal, Sonali, Wang, Zhiqiang, Ma, Wencai, Zhang, Min, Ruvolo, Peter, Ruvolo, Vivian, Wang, Rui-Yu, McQueen, Teresa, Lowe, Scott, Zuber, Johannes, Kornblau, Steven M., Konopleva, Marina, Andreeff, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663521/ https://www.ncbi.nlm.nih.gov/pubmed/29137349 http://dx.doi.org/10.18632/oncotarget.19042

Ejemplares similares

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34(+) proliferating and quiescent chronic myeloid leukemia blast crisis cells
por: Carter, Bing Z., et al.
Publicado: (2015)

Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival
por: Kornblau, Steven M., et al.
Publicado: (2018)

MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation
por: Borthakur, Gautam, et al.
Publicado: (2015)

Low Expression Of PP2A Regulatory Subunit B55α Is Associated With T308 Phosphorylation Of AKT And Shorter Complete Remission Duration In Acute Myeloid Leukemia Patients
por: Ruvolo, Peter P., et al.
Publicado: (2011)

Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients
por: Ruvolo, Peter P., et al.
Publicado: (2015)

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network
por: Carter, Bing Z., et al.
Publicado: (2016)

TRP ion channels in thermosensation, thermoregulation and metabolism
por: Wang, Hong, et al.
Publicado: (2015)

TRP channels and temperature in airway disease—clinical significance
por: Millqvist, Eva
Publicado: (2015)

Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs
por: Ishizawa, Jo, et al.
Publicado: (2015)

Bone marrow stromal cells induce an ALDH(+) stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway
por: Yuan, Bin, et al.
Publicado: (2020)

Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8
por: Carrasquel-Ursulaez, Willy, et al.
Publicado: (2015)

LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML
por: Ruvolo, Peter P., et al.
Publicado: (2019)

In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment
por: Franke, Katharina, et al.
Publicado: (2015)

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
por: Carter, Bing Z., et al.
Publicado: (2023)

Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
por: Carter, Bing Z., et al.
Publicado: (2023)

Radiofrequency Ablation Remodels the Tumor Microenvironment and Promotes Neutrophil-Mediated Abscopal Immunomodulation in Pancreatic Cancer
por: Faraoni, Erika Y., et al.
Publicado: (2023)

Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial
por: Zhang, Weiguo, et al.
Publicado: (2018)

Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML
por: Tabe, Yoko, et al.
Publicado: (2020)

Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms
por: Ruvolo, Peter P., et al.
Publicado: (2017)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias
por: Nishida, Yuki, et al.
Publicado: (2023)

p53 and rapamycin are additive
por: Christy, Barbara, et al.
Publicado: (2015)

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill F LT 3-ITD acute myeloid leukemia
por: Post, Sean M., et al.
Publicado: (2021)

Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy
por: Zhang, Weiguo, et al.
Publicado: (2022)

Trp53 regulates platelets in bone marrow via the PI3K pathway
por: Yang, Mingming, et al.
Publicado: (2020)

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity
por: van der Weyden, L, et al.
Publicado: (2013)

IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2(+) cancer stem cells
por: Battula, Venkata Lokesh, et al.
Publicado: (2017)

p53-independent p21 induction by MELK inhibition
por: Matsuda, Tatsuo, et al.
Publicado: (2017)

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
por: Tabe, Yoko, et al.
Publicado: (2018)

Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment
por: Shay, Gemma, et al.
Publicado: (2017)

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition
por: Saito, Kaori, et al.
Publicado: (2021)

Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment
por: Stodden, Genna R., et al.
Publicado: (2014)

p53-regulated autophagy is controlled by glycolysis and determines cell fate
por: Duan, Lei, et al.
Publicado: (2015)

p21 can be a barrier to ferroptosis independent of p53
por: Venkatesh, Divya, et al.
Publicado: (2020)

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
por: Lohse, Ines, et al.
Publicado: (2016)

Identification of a p53-repressed gene module in breast cancer cells
por: Miyamoto, Takafumi, et al.
Publicado: (2017)

The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells
por: Nwajei, Felix, et al.
Publicado: (2013)

cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad
por: McGee, Mathew D., et al.
Publicado: (2012)

TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment
por: Tabe, Yoko, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_er1g5gn0mf6fvsrnmdqvar6ije