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Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells
Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. We have previously reported that GRN163L could shorten telomeres and limit the lifespan of CD18/HPAF and CAPAN1 pancreatic cancer cells. Here, we examined the effects of GRN163L on two other pancreatic cancer cell lines: AsPC1 a...
Autores principales: | Burchett, Katrina M., Etekpo, Asserewou, Batra, Surinder K., Yan, Ying, Ouellette, Michel M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663552/ https://www.ncbi.nlm.nih.gov/pubmed/29137380 http://dx.doi.org/10.18632/oncotarget.19410 |
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