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Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis

Although Ginsenoside Rg1 has been reported to have protective cardiac effects, its effects on cardiac toxicity induced by doxorubicin needs to be studied. The present study investigated the effects of oral administration of Rg1 on the heart in mice treated with doxorubicin and found improved fractio...

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Detalles Bibliográficos
Autores principales: Zhu, Chen, Wang, Yi, Liu, Hua, Mu, Haiman, Lu, Yue, Zhang, Jiayi, Huang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663555/
https://www.ncbi.nlm.nih.gov/pubmed/29137383
http://dx.doi.org/10.18632/oncotarget.19698
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author Zhu, Chen
Wang, Yi
Liu, Hua
Mu, Haiman
Lu, Yue
Zhang, Jiayi
Huang, Jianhua
author_facet Zhu, Chen
Wang, Yi
Liu, Hua
Mu, Haiman
Lu, Yue
Zhang, Jiayi
Huang, Jianhua
author_sort Zhu, Chen
collection PubMed
description Although Ginsenoside Rg1 has been reported to have protective cardiac effects, its effects on cardiac toxicity induced by doxorubicin needs to be studied. The present study investigated the effects of oral administration of Rg1 on the heart in mice treated with doxorubicin and found improved fractional shortening and ejection fraction of the heart and decreased cardiac apoptosis in mice treated with doxorubicin. The underlying mechanisms include increased phosphorylation of Akt and Erk by Rg1, increased ratio of Bcl-2 and Bax, and decreased release of cytochrome c from mitochondria, thereby protecting the heart from doxorubicin-induced apoptosis. This phenotype suggested that the oral administration of Rg1 may be a potential method preventing the cardiac toxicity caused by doxorubicin in clinical practice.
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spelling pubmed-56635552017-11-13 Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis Zhu, Chen Wang, Yi Liu, Hua Mu, Haiman Lu, Yue Zhang, Jiayi Huang, Jianhua Oncotarget Research Paper Although Ginsenoside Rg1 has been reported to have protective cardiac effects, its effects on cardiac toxicity induced by doxorubicin needs to be studied. The present study investigated the effects of oral administration of Rg1 on the heart in mice treated with doxorubicin and found improved fractional shortening and ejection fraction of the heart and decreased cardiac apoptosis in mice treated with doxorubicin. The underlying mechanisms include increased phosphorylation of Akt and Erk by Rg1, increased ratio of Bcl-2 and Bax, and decreased release of cytochrome c from mitochondria, thereby protecting the heart from doxorubicin-induced apoptosis. This phenotype suggested that the oral administration of Rg1 may be a potential method preventing the cardiac toxicity caused by doxorubicin in clinical practice. Impact Journals LLC 2017-07-31 /pmc/articles/PMC5663555/ /pubmed/29137383 http://dx.doi.org/10.18632/oncotarget.19698 Text en Copyright: © 2017 Zhu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhu, Chen
Wang, Yi
Liu, Hua
Mu, Haiman
Lu, Yue
Zhang, Jiayi
Huang, Jianhua
Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
title Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
title_full Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
title_fullStr Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
title_full_unstemmed Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
title_short Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
title_sort oral administration of ginsenoside rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663555/
https://www.ncbi.nlm.nih.gov/pubmed/29137383
http://dx.doi.org/10.18632/oncotarget.19698
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