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DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage

Hexavalent chromium (Cr[VI]) is associated with occupational lung cancer and poses a significant public health concern. When exposed to Cr[VI], cells rapidly internalize this compound and metabolize it to Cr[III]. Byproducts of Cr[VI] metabolism include unstable Cr[V] and Cr[IV] intermediates that a...

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Detalles Bibliográficos
Autores principales:	Wakeman, Timothy P., Yang, Aimin, Dalal, Naresh S., Boohaker, Rebecca J., Zeng, Qinghua, Ding, Qiang, Xu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663569/ https://www.ncbi.nlm.nih.gov/pubmed/29137397 http://dx.doi.org/10.18632/oncotarget.20150

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