Cargando…
Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
BACKGROUND AND AIM: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. RESULTS: One hund...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663577/ https://www.ncbi.nlm.nih.gov/pubmed/29137405 http://dx.doi.org/10.18632/oncotarget.21099 |
_version_ | 1783274837991489536 |
---|---|
author | Wang, Bing Li, Jian Gao, Hong-Mei Xing, Ying-Hong Lin, Zhu Li, Hong-Jie Wang, Yong-Qiang |
author_facet | Wang, Bing Li, Jian Gao, Hong-Mei Xing, Ying-Hong Lin, Zhu Li, Hong-Jie Wang, Yong-Qiang |
author_sort | Wang, Bing |
collection | PubMed |
description | BACKGROUND AND AIM: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. RESULTS: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock. The RIPK3 levels in the severe sepsis and septic shock groups were notably higher than those in sepsis group at various time points (all p < 0.05), and the RIPK3 levels had positive association with the Sequential Organ Failure Assessment (SOFA) score as well as procalcitonin (PCT) level (all p < 0.05). The RIPK3 level like the SOFA score and PCT level could be a prognostic biomarker of sepsis patients. MATERIALS AND METHODS: We prospectively recruited the eligible patients with sepsis, severe sepsis, or septic shock who were treated in our hospital from January 2014 to May 2016. The dynamic changes in infectious variables and blood plasma receptor interacting protein kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3) levels were determined from measurements taken in a double-blinded fashion at 24, 48, 72, and 120 hours later. CONCLUSIONS: These results suggested that dynamic monitoring of RIPK3 levels can contribute to the prediction of outcome of sepsis and might be of particular value in identifying patients who would benefit from specific treatments. |
format | Online Article Text |
id | pubmed-5663577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56635772017-11-13 Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study Wang, Bing Li, Jian Gao, Hong-Mei Xing, Ying-Hong Lin, Zhu Li, Hong-Jie Wang, Yong-Qiang Oncotarget Research Paper BACKGROUND AND AIM: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. RESULTS: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock. The RIPK3 levels in the severe sepsis and septic shock groups were notably higher than those in sepsis group at various time points (all p < 0.05), and the RIPK3 levels had positive association with the Sequential Organ Failure Assessment (SOFA) score as well as procalcitonin (PCT) level (all p < 0.05). The RIPK3 level like the SOFA score and PCT level could be a prognostic biomarker of sepsis patients. MATERIALS AND METHODS: We prospectively recruited the eligible patients with sepsis, severe sepsis, or septic shock who were treated in our hospital from January 2014 to May 2016. The dynamic changes in infectious variables and blood plasma receptor interacting protein kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3) levels were determined from measurements taken in a double-blinded fashion at 24, 48, 72, and 120 hours later. CONCLUSIONS: These results suggested that dynamic monitoring of RIPK3 levels can contribute to the prediction of outcome of sepsis and might be of particular value in identifying patients who would benefit from specific treatments. Impact Journals LLC 2017-09-20 /pmc/articles/PMC5663577/ /pubmed/29137405 http://dx.doi.org/10.18632/oncotarget.21099 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Bing Li, Jian Gao, Hong-Mei Xing, Ying-Hong Lin, Zhu Li, Hong-Jie Wang, Yong-Qiang Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
title | Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
title_full | Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
title_fullStr | Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
title_full_unstemmed | Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
title_short | Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
title_sort | necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663577/ https://www.ncbi.nlm.nih.gov/pubmed/29137405 http://dx.doi.org/10.18632/oncotarget.21099 |
work_keys_str_mv | AT wangbing necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy AT lijian necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy AT gaohongmei necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy AT xingyinghong necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy AT linzhu necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy AT lihongjie necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy AT wangyongqiang necroptosisregulatedproteinsexpressionisanearlyprognosticbiomarkerinpatientwithsepsisaprospectiveobservationalstudy |