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Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study

BACKGROUND AND AIM: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. RESULTS: One hund...

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Autores principales: Wang, Bing, Li, Jian, Gao, Hong-Mei, Xing, Ying-Hong, Lin, Zhu, Li, Hong-Jie, Wang, Yong-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663577/
https://www.ncbi.nlm.nih.gov/pubmed/29137405
http://dx.doi.org/10.18632/oncotarget.21099
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author Wang, Bing
Li, Jian
Gao, Hong-Mei
Xing, Ying-Hong
Lin, Zhu
Li, Hong-Jie
Wang, Yong-Qiang
author_facet Wang, Bing
Li, Jian
Gao, Hong-Mei
Xing, Ying-Hong
Lin, Zhu
Li, Hong-Jie
Wang, Yong-Qiang
author_sort Wang, Bing
collection PubMed
description BACKGROUND AND AIM: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. RESULTS: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock. The RIPK3 levels in the severe sepsis and septic shock groups were notably higher than those in sepsis group at various time points (all p < 0.05), and the RIPK3 levels had positive association with the Sequential Organ Failure Assessment (SOFA) score as well as procalcitonin (PCT) level (all p < 0.05). The RIPK3 level like the SOFA score and PCT level could be a prognostic biomarker of sepsis patients. MATERIALS AND METHODS: We prospectively recruited the eligible patients with sepsis, severe sepsis, or septic shock who were treated in our hospital from January 2014 to May 2016. The dynamic changes in infectious variables and blood plasma receptor interacting protein kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3) levels were determined from measurements taken in a double-blinded fashion at 24, 48, 72, and 120 hours later. CONCLUSIONS: These results suggested that dynamic monitoring of RIPK3 levels can contribute to the prediction of outcome of sepsis and might be of particular value in identifying patients who would benefit from specific treatments.
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spelling pubmed-56635772017-11-13 Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study Wang, Bing Li, Jian Gao, Hong-Mei Xing, Ying-Hong Lin, Zhu Li, Hong-Jie Wang, Yong-Qiang Oncotarget Research Paper BACKGROUND AND AIM: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients. RESULTS: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock. The RIPK3 levels in the severe sepsis and septic shock groups were notably higher than those in sepsis group at various time points (all p < 0.05), and the RIPK3 levels had positive association with the Sequential Organ Failure Assessment (SOFA) score as well as procalcitonin (PCT) level (all p < 0.05). The RIPK3 level like the SOFA score and PCT level could be a prognostic biomarker of sepsis patients. MATERIALS AND METHODS: We prospectively recruited the eligible patients with sepsis, severe sepsis, or septic shock who were treated in our hospital from January 2014 to May 2016. The dynamic changes in infectious variables and blood plasma receptor interacting protein kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3) levels were determined from measurements taken in a double-blinded fashion at 24, 48, 72, and 120 hours later. CONCLUSIONS: These results suggested that dynamic monitoring of RIPK3 levels can contribute to the prediction of outcome of sepsis and might be of particular value in identifying patients who would benefit from specific treatments. Impact Journals LLC 2017-09-20 /pmc/articles/PMC5663577/ /pubmed/29137405 http://dx.doi.org/10.18632/oncotarget.21099 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Bing
Li, Jian
Gao, Hong-Mei
Xing, Ying-Hong
Lin, Zhu
Li, Hong-Jie
Wang, Yong-Qiang
Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
title Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
title_full Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
title_fullStr Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
title_full_unstemmed Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
title_short Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
title_sort necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663577/
https://www.ncbi.nlm.nih.gov/pubmed/29137405
http://dx.doi.org/10.18632/oncotarget.21099
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