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Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis
Evidence suggests that immune system alterations in Down syndrome (DS) may be early events that drive neuropathological and cognitive changes of Alzheimer's disease. The primary objective of this meta-analysis was to investigate whether there is an abnormal cytokine profile in DS patients when...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663613/ https://www.ncbi.nlm.nih.gov/pubmed/29137441 http://dx.doi.org/10.18632/oncotarget.21060 |
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author | Zhang, Yan Che, Meng Yuan, Jing Yu, Yun Cao, Chang Qin, Xiao-Yan Cheng, Yong |
author_facet | Zhang, Yan Che, Meng Yuan, Jing Yu, Yun Cao, Chang Qin, Xiao-Yan Cheng, Yong |
author_sort | Zhang, Yan |
collection | PubMed |
description | Evidence suggests that immune system alterations in Down syndrome (DS) may be early events that drive neuropathological and cognitive changes of Alzheimer's disease. The primary objective of this meta-analysis was to investigate whether there is an abnormal cytokine profile in DS patients when compared with healthy control (HC) subjects. A systematic search of Pubmed and Web of Science identified 19 studies with 957 DS patients and 541 HC subjects for this meta-analysis. Random effects meta-analysis demonstrated that patients with DS had significantly increased circulating tumor necrosis factor-α (Hedges’ g = 1.045, 95% confidence interval (CI) = 0.192 to 1.898, p = 0.016), interleukin (IL)-1β (Hedges’ g = 0.696, 95% confidence CI = 0.149 to 1.242, p = 0.013), interferon-γ (Hedges’ g = 0.978, 95% CI = 0.417 to 1.539, p = 0.001) and neopterin (Hedges’ g = 0.815, 95% CI = 0.423 to 1.207, p < 0.001) levels compared to HC subjects. No significant differences were found between patients with DS and controls for concentrations of IL-4, IL-6, IL8 and IL-10. In addition, most of the cytokine data in this meta-analysis were from children with DS and HC, and subgroup analysis showed that children with DS had elevated tumor necrosis factor-α, IL-1β and interferon-γ levels when compared with controls. Taken together, these results demonstrated that patients (children) with DS are accompanied by increased circulating cytokine tumor necrosis factor-α, IL-1β and interferon-γ levels, strengthening the clinical evidence that patients (children) with DS are accompanied by an abnormal inflammatory response. |
format | Online Article Text |
id | pubmed-5663613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56636132017-11-13 Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis Zhang, Yan Che, Meng Yuan, Jing Yu, Yun Cao, Chang Qin, Xiao-Yan Cheng, Yong Oncotarget Meta-Analysis Evidence suggests that immune system alterations in Down syndrome (DS) may be early events that drive neuropathological and cognitive changes of Alzheimer's disease. The primary objective of this meta-analysis was to investigate whether there is an abnormal cytokine profile in DS patients when compared with healthy control (HC) subjects. A systematic search of Pubmed and Web of Science identified 19 studies with 957 DS patients and 541 HC subjects for this meta-analysis. Random effects meta-analysis demonstrated that patients with DS had significantly increased circulating tumor necrosis factor-α (Hedges’ g = 1.045, 95% confidence interval (CI) = 0.192 to 1.898, p = 0.016), interleukin (IL)-1β (Hedges’ g = 0.696, 95% confidence CI = 0.149 to 1.242, p = 0.013), interferon-γ (Hedges’ g = 0.978, 95% CI = 0.417 to 1.539, p = 0.001) and neopterin (Hedges’ g = 0.815, 95% CI = 0.423 to 1.207, p < 0.001) levels compared to HC subjects. No significant differences were found between patients with DS and controls for concentrations of IL-4, IL-6, IL8 and IL-10. In addition, most of the cytokine data in this meta-analysis were from children with DS and HC, and subgroup analysis showed that children with DS had elevated tumor necrosis factor-α, IL-1β and interferon-γ levels when compared with controls. Taken together, these results demonstrated that patients (children) with DS are accompanied by increased circulating cytokine tumor necrosis factor-α, IL-1β and interferon-γ levels, strengthening the clinical evidence that patients (children) with DS are accompanied by an abnormal inflammatory response. Impact Journals LLC 2017-09-19 /pmc/articles/PMC5663613/ /pubmed/29137441 http://dx.doi.org/10.18632/oncotarget.21060 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Zhang, Yan Che, Meng Yuan, Jing Yu, Yun Cao, Chang Qin, Xiao-Yan Cheng, Yong Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis |
title | Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis |
title_full | Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis |
title_fullStr | Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis |
title_full_unstemmed | Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis |
title_short | Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis |
title_sort | aberrations in circulating inflammatory cytokine levels in patients with down syndrome: a meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663613/ https://www.ncbi.nlm.nih.gov/pubmed/29137441 http://dx.doi.org/10.18632/oncotarget.21060 |
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