MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

Severe hepatic inflammation is a common cause of acute liver injury following systemic infection with Ehrlichia, obligate Gram-negative intracellular bacteria that lack lipopolysaccharide (LPS). We have previously shown that type I IFN (IFN-I) and inflammasome activation are key host-pathogenic medi...

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Detalles Bibliográficos
Autores principales: Kader, Muhamuda, Alaoui-EL-Azher, Mounia, Vorhauer, Jennie, Kode, Bhushan B, Wells, Jakob Z., Stolz, Donna, Michalopoulos, George, Wells, Alan, Scott, Melanie, Ismail, Nahed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663626/
https://www.ncbi.nlm.nih.gov/pubmed/29049365
http://dx.doi.org/10.1371/journal.ppat.1006644

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