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Quantifying the benefit of a proteome reserve in fluctuating environments
The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome of Escherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth. Here, we quantitatively investigate the possibility tha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663898/ https://www.ncbi.nlm.nih.gov/pubmed/29089487 http://dx.doi.org/10.1038/s41467-017-01242-8 |
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author | Mori, Matteo Schink, Severin Erickson, David W. Gerland, Ulrich Hwa, Terence |
author_facet | Mori, Matteo Schink, Severin Erickson, David W. Gerland, Ulrich Hwa, Terence |
author_sort | Mori, Matteo |
collection | PubMed |
description | The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome of Escherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth. Here, we quantitatively investigate the possibility that this overexpression constitutes a strategic reserve kept by starving cells to quickly meet demand upon sudden improvement in growth conditions. For cells exposed to repeated famine-and-feast cycles, we derive a simple relation between the duration of feast and the allocation of the ribosomal protein reserve to maximize the overall gain in biomass during the feast. |
format | Online Article Text |
id | pubmed-5663898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56638982017-11-02 Quantifying the benefit of a proteome reserve in fluctuating environments Mori, Matteo Schink, Severin Erickson, David W. Gerland, Ulrich Hwa, Terence Nat Commun Article The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome of Escherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth. Here, we quantitatively investigate the possibility that this overexpression constitutes a strategic reserve kept by starving cells to quickly meet demand upon sudden improvement in growth conditions. For cells exposed to repeated famine-and-feast cycles, we derive a simple relation between the duration of feast and the allocation of the ribosomal protein reserve to maximize the overall gain in biomass during the feast. Nature Publishing Group UK 2017-10-31 /pmc/articles/PMC5663898/ /pubmed/29089487 http://dx.doi.org/10.1038/s41467-017-01242-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mori, Matteo Schink, Severin Erickson, David W. Gerland, Ulrich Hwa, Terence Quantifying the benefit of a proteome reserve in fluctuating environments |
title | Quantifying the benefit of a proteome reserve in fluctuating environments |
title_full | Quantifying the benefit of a proteome reserve in fluctuating environments |
title_fullStr | Quantifying the benefit of a proteome reserve in fluctuating environments |
title_full_unstemmed | Quantifying the benefit of a proteome reserve in fluctuating environments |
title_short | Quantifying the benefit of a proteome reserve in fluctuating environments |
title_sort | quantifying the benefit of a proteome reserve in fluctuating environments |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663898/ https://www.ncbi.nlm.nih.gov/pubmed/29089487 http://dx.doi.org/10.1038/s41467-017-01242-8 |
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