Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors. Our analysis defines 96 genomic regions...

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Detalles Bibliográficos
Autores principales: Cheng, Jiqiu, Demeulemeester, Jonas, Wedge, David C., Vollan, Hans Kristian M., Pitt, Jason J., Russnes, Hege G., Pandey, Bina P., Nilsen, Gro, Nord, Silje, Bignell, Graham R., White, Kevin P., Børresen-Dale, Anne-Lise, Campbell, Peter J., Kristensen, Vessela N., Stratton, Michael R., Lingjærde, Ole Christian, Moreau, Yves, Van Loo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663922/
https://www.ncbi.nlm.nih.gov/pubmed/29089486
http://dx.doi.org/10.1038/s41467-017-01355-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663922/
https://www.ncbi.nlm.nih.gov/pubmed/29089486
http://dx.doi.org/10.1038/s41467-017-01355-0

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