Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Rac small GTPases and their GEFs of the DOCK family are pivotal checkpoints in development, autoimmunity and bone homeostasis, and their abnormal regulation is associated to diverse pathologies. Small molecules that inhibit their activities are therefore needed to investigate their functions. Here,...

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Detalles Bibliográficos
Autores principales: Ferrandez, Yann, Zhang, Wenhua, Peurois, François, Akendengué, Lurlène, Blangy, Anne, Zeghouf, Mahel, Cherfils, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663973/
https://www.ncbi.nlm.nih.gov/pubmed/29089502
http://dx.doi.org/10.1038/s41598-017-13619-2

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