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Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications

The curse of ancient Egyptian DNA was lifted by a recent study which sequenced the mitochondrial genomes (mtGenome) of 90 ancient Egyptians from the archaeological site of Abusir el-Meleq. Surprisingly, these ancient inhabitants were more closely related to those from the Near East than to contempor...

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Autores principales: Molto, J. Eldon, Loreille, Odile, Mallott, Elizabeth K., Malhi, Ripan S., Fast, Spence, Daniels-Higginbotham, Jennifer, Marshall, Charla, Parr, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664112/
https://www.ncbi.nlm.nih.gov/pubmed/28984839
http://dx.doi.org/10.3390/genes8100262
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author Molto, J. Eldon
Loreille, Odile
Mallott, Elizabeth K.
Malhi, Ripan S.
Fast, Spence
Daniels-Higginbotham, Jennifer
Marshall, Charla
Parr, Ryan
author_facet Molto, J. Eldon
Loreille, Odile
Mallott, Elizabeth K.
Malhi, Ripan S.
Fast, Spence
Daniels-Higginbotham, Jennifer
Marshall, Charla
Parr, Ryan
author_sort Molto, J. Eldon
collection PubMed
description The curse of ancient Egyptian DNA was lifted by a recent study which sequenced the mitochondrial genomes (mtGenome) of 90 ancient Egyptians from the archaeological site of Abusir el-Meleq. Surprisingly, these ancient inhabitants were more closely related to those from the Near East than to contemporary Egyptians. It has been accepted that the timeless highway of the Nile River seeded Egypt with African genetic influence, well before pre-Dynastic times. Here we report on the successful recovery and analysis of the complete mtGenome from a burial recovered from a remote Romano–Christian cemetery, Kellis 2 (K2). K2 serviced the ancient municipality of Kellis, a village located in the Dakhleh Oasis in the southwest desert in Egypt. The data were obtained by high throughput sequencing (HTS) performed independently at two ancient DNA facilities (Armed Forces DNA Identification Laboratory, Dover, DE, USA and Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA). These efforts produced concordant haplotypes representing a U1a1a haplogroup lineage. This result indicates that Near Eastern maternal influence previously identified at Abusir el-Meleq was also present further south, in ancient Kellis during the Romano–Christian period.
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spelling pubmed-56641122017-11-06 Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications Molto, J. Eldon Loreille, Odile Mallott, Elizabeth K. Malhi, Ripan S. Fast, Spence Daniels-Higginbotham, Jennifer Marshall, Charla Parr, Ryan Genes (Basel) Article The curse of ancient Egyptian DNA was lifted by a recent study which sequenced the mitochondrial genomes (mtGenome) of 90 ancient Egyptians from the archaeological site of Abusir el-Meleq. Surprisingly, these ancient inhabitants were more closely related to those from the Near East than to contemporary Egyptians. It has been accepted that the timeless highway of the Nile River seeded Egypt with African genetic influence, well before pre-Dynastic times. Here we report on the successful recovery and analysis of the complete mtGenome from a burial recovered from a remote Romano–Christian cemetery, Kellis 2 (K2). K2 serviced the ancient municipality of Kellis, a village located in the Dakhleh Oasis in the southwest desert in Egypt. The data were obtained by high throughput sequencing (HTS) performed independently at two ancient DNA facilities (Armed Forces DNA Identification Laboratory, Dover, DE, USA and Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA). These efforts produced concordant haplotypes representing a U1a1a haplogroup lineage. This result indicates that Near Eastern maternal influence previously identified at Abusir el-Meleq was also present further south, in ancient Kellis during the Romano–Christian period. MDPI 2017-10-06 /pmc/articles/PMC5664112/ /pubmed/28984839 http://dx.doi.org/10.3390/genes8100262 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Molto, J. Eldon
Loreille, Odile
Mallott, Elizabeth K.
Malhi, Ripan S.
Fast, Spence
Daniels-Higginbotham, Jennifer
Marshall, Charla
Parr, Ryan
Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications
title Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications
title_full Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications
title_fullStr Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications
title_full_unstemmed Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications
title_short Complete Mitochondrial Genome Sequencing of a Burial from a Romano–Christian Cemetery in the Dakhleh Oasis, Egypt: Preliminary Indications
title_sort complete mitochondrial genome sequencing of a burial from a romano–christian cemetery in the dakhleh oasis, egypt: preliminary indications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664112/
https://www.ncbi.nlm.nih.gov/pubmed/28984839
http://dx.doi.org/10.3390/genes8100262
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