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Brain network connectivity differs in early-onset neurodegenerative dementia

OBJECTIVE: To investigate functional brain network architecture in early-onset Alzheimer disease (EOAD) and behavioral variant frontotemporal dementia (bvFTD). METHODS: Thirty-eight patients with bvFTD, 37 patients with EOAD, and 32 age-matched healthy controls underwent 3D T1-weighted and resting-s...

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Autores principales: Filippi, Massimo, Basaia, Silvia, Canu, Elisa, Imperiale, Francesca, Meani, Alessandro, Caso, Francesca, Magnani, Giuseppe, Falautano, Monica, Comi, Giancarlo, Falini, Andrea, Agosta, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664301/
https://www.ncbi.nlm.nih.gov/pubmed/28954876
http://dx.doi.org/10.1212/WNL.0000000000004577
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author Filippi, Massimo
Basaia, Silvia
Canu, Elisa
Imperiale, Francesca
Meani, Alessandro
Caso, Francesca
Magnani, Giuseppe
Falautano, Monica
Comi, Giancarlo
Falini, Andrea
Agosta, Federica
author_facet Filippi, Massimo
Basaia, Silvia
Canu, Elisa
Imperiale, Francesca
Meani, Alessandro
Caso, Francesca
Magnani, Giuseppe
Falautano, Monica
Comi, Giancarlo
Falini, Andrea
Agosta, Federica
author_sort Filippi, Massimo
collection PubMed
description OBJECTIVE: To investigate functional brain network architecture in early-onset Alzheimer disease (EOAD) and behavioral variant frontotemporal dementia (bvFTD). METHODS: Thirty-eight patients with bvFTD, 37 patients with EOAD, and 32 age-matched healthy controls underwent 3D T1-weighted and resting-state fMRI. Graph analysis and connectomics assessed global and local functional topologic network properties, regional functional connectivity, and intrahemispheric and interhemispheric between-lobe connectivity. RESULTS: Despite similarly extensive cognitive impairment relative to controls, patients with EOAD showed severe global functional network alterations (lower mean nodal strength, local efficiency, clustering coefficient, and longer path length), while patients with bvFTD showed relatively preserved global functional brain architecture. Patients with bvFTD demonstrated reduced nodal strength in the frontoinsular lobe and a relatively focal altered functional connectivity of frontoinsular and temporal regions. Functional connectivity breakdown in the posterior brain nodes, particularly in the parietal lobe, differentiated patients with EOAD from those with bvFTD. While EOAD was associated with widespread loss of both intrahemispheric and interhemispheric functional correlations, bvFTD showed a preferential disruption of the intrahemispheric connectivity. CONCLUSIONS: Disease-specific patterns of functional network topology and connectivity alterations were observed in patients with EOAD and bvFTD. Graph analysis and connectomics may aid clinical diagnosis and help elucidate pathophysiologic differences between neurodegenerative dementias.
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spelling pubmed-56643012017-11-03 Brain network connectivity differs in early-onset neurodegenerative dementia Filippi, Massimo Basaia, Silvia Canu, Elisa Imperiale, Francesca Meani, Alessandro Caso, Francesca Magnani, Giuseppe Falautano, Monica Comi, Giancarlo Falini, Andrea Agosta, Federica Neurology Article OBJECTIVE: To investigate functional brain network architecture in early-onset Alzheimer disease (EOAD) and behavioral variant frontotemporal dementia (bvFTD). METHODS: Thirty-eight patients with bvFTD, 37 patients with EOAD, and 32 age-matched healthy controls underwent 3D T1-weighted and resting-state fMRI. Graph analysis and connectomics assessed global and local functional topologic network properties, regional functional connectivity, and intrahemispheric and interhemispheric between-lobe connectivity. RESULTS: Despite similarly extensive cognitive impairment relative to controls, patients with EOAD showed severe global functional network alterations (lower mean nodal strength, local efficiency, clustering coefficient, and longer path length), while patients with bvFTD showed relatively preserved global functional brain architecture. Patients with bvFTD demonstrated reduced nodal strength in the frontoinsular lobe and a relatively focal altered functional connectivity of frontoinsular and temporal regions. Functional connectivity breakdown in the posterior brain nodes, particularly in the parietal lobe, differentiated patients with EOAD from those with bvFTD. While EOAD was associated with widespread loss of both intrahemispheric and interhemispheric functional correlations, bvFTD showed a preferential disruption of the intrahemispheric connectivity. CONCLUSIONS: Disease-specific patterns of functional network topology and connectivity alterations were observed in patients with EOAD and bvFTD. Graph analysis and connectomics may aid clinical diagnosis and help elucidate pathophysiologic differences between neurodegenerative dementias. Lippincott Williams & Wilkins 2017-10-24 /pmc/articles/PMC5664301/ /pubmed/28954876 http://dx.doi.org/10.1212/WNL.0000000000004577 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Filippi, Massimo
Basaia, Silvia
Canu, Elisa
Imperiale, Francesca
Meani, Alessandro
Caso, Francesca
Magnani, Giuseppe
Falautano, Monica
Comi, Giancarlo
Falini, Andrea
Agosta, Federica
Brain network connectivity differs in early-onset neurodegenerative dementia
title Brain network connectivity differs in early-onset neurodegenerative dementia
title_full Brain network connectivity differs in early-onset neurodegenerative dementia
title_fullStr Brain network connectivity differs in early-onset neurodegenerative dementia
title_full_unstemmed Brain network connectivity differs in early-onset neurodegenerative dementia
title_short Brain network connectivity differs in early-onset neurodegenerative dementia
title_sort brain network connectivity differs in early-onset neurodegenerative dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664301/
https://www.ncbi.nlm.nih.gov/pubmed/28954876
http://dx.doi.org/10.1212/WNL.0000000000004577
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