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Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes

This study investigated the hypoglycemic, antihyperlipidemic, and renoprotective potentials of Dennettia tripetala (DT) in a rat model of diabetes. The hypoglycemic activity in crude methanol seed extract of DT (CMEDT) and methanol seed fraction of DT (MFDT) measured by glucose oxidase method was in...

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Autores principales: Anioke, Innocent, Okwuosa, Chukwugozie, Uchendu, Ikenna, Chijioke, Olive, Dozie-Nwakile, Ogechukwu, Ikegwuonu, Ifeoma, Kalu, Peculiar, Okafor, Maryann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664378/
https://www.ncbi.nlm.nih.gov/pubmed/29181401
http://dx.doi.org/10.1155/2017/6923629
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author Anioke, Innocent
Okwuosa, Chukwugozie
Uchendu, Ikenna
Chijioke, Olive
Dozie-Nwakile, Ogechukwu
Ikegwuonu, Ifeoma
Kalu, Peculiar
Okafor, Maryann
author_facet Anioke, Innocent
Okwuosa, Chukwugozie
Uchendu, Ikenna
Chijioke, Olive
Dozie-Nwakile, Ogechukwu
Ikegwuonu, Ifeoma
Kalu, Peculiar
Okafor, Maryann
author_sort Anioke, Innocent
collection PubMed
description This study investigated the hypoglycemic, antihyperlipidemic, and renoprotective potentials of Dennettia tripetala (DT) in a rat model of diabetes. The hypoglycemic activity in crude methanol seed extract of DT (CMEDT) and methanol seed fraction of DT (MFDT) measured by glucose oxidase method was increased by 47.37% and 28.72%, respectively, after 8 hours of administration. After 10 days of treatment, CMEDT and MFDT gave a good glycemic control with the highest percentage reduction of 75.82% and 71.34% in glucose level, respectively, which is closely compared with 79.91% in glibenclamide. Using the enzymatic assay and Friedewald's equation, there was a significant reduction in serum level of total cholesterol (TC), triglyceride (TG), very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) and a significant increase in high-density lipoprotein (HDL) (p < 0.05) following treatment with CMEDT and MFDT, when compared with the untreated group, although results varied in dosed groups, with high dose of MFDT showing a better lipid-lowering activity. High dose of MFDT improved lipid metabolism and increased percentage protection against atherogenesis by 44%. However, neither CMEDT nor MFDT ameliorated the renal biochemical alteration in urea and creatinine. Thus, the study demonstrates hypoglycemic and antihyperlipidemic potentials of DT seed in diabetes.
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spelling pubmed-56643782017-11-27 Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes Anioke, Innocent Okwuosa, Chukwugozie Uchendu, Ikenna Chijioke, Olive Dozie-Nwakile, Ogechukwu Ikegwuonu, Ifeoma Kalu, Peculiar Okafor, Maryann Biomed Res Int Research Article This study investigated the hypoglycemic, antihyperlipidemic, and renoprotective potentials of Dennettia tripetala (DT) in a rat model of diabetes. The hypoglycemic activity in crude methanol seed extract of DT (CMEDT) and methanol seed fraction of DT (MFDT) measured by glucose oxidase method was increased by 47.37% and 28.72%, respectively, after 8 hours of administration. After 10 days of treatment, CMEDT and MFDT gave a good glycemic control with the highest percentage reduction of 75.82% and 71.34% in glucose level, respectively, which is closely compared with 79.91% in glibenclamide. Using the enzymatic assay and Friedewald's equation, there was a significant reduction in serum level of total cholesterol (TC), triglyceride (TG), very-low-density lipoprotein (VLDL), and low-density lipoprotein (LDL) and a significant increase in high-density lipoprotein (HDL) (p < 0.05) following treatment with CMEDT and MFDT, when compared with the untreated group, although results varied in dosed groups, with high dose of MFDT showing a better lipid-lowering activity. High dose of MFDT improved lipid metabolism and increased percentage protection against atherogenesis by 44%. However, neither CMEDT nor MFDT ameliorated the renal biochemical alteration in urea and creatinine. Thus, the study demonstrates hypoglycemic and antihyperlipidemic potentials of DT seed in diabetes. Hindawi 2017 2017-10-17 /pmc/articles/PMC5664378/ /pubmed/29181401 http://dx.doi.org/10.1155/2017/6923629 Text en Copyright © 2017 Innocent Anioke et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Anioke, Innocent
Okwuosa, Chukwugozie
Uchendu, Ikenna
Chijioke, Olive
Dozie-Nwakile, Ogechukwu
Ikegwuonu, Ifeoma
Kalu, Peculiar
Okafor, Maryann
Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
title Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
title_full Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
title_fullStr Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
title_full_unstemmed Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
title_short Investigation into Hypoglycemic, Antihyperlipidemic, and Renoprotective Potentials of Dennettia tripetala (Pepper Fruit) Seed in a Rat Model of Diabetes
title_sort investigation into hypoglycemic, antihyperlipidemic, and renoprotective potentials of dennettia tripetala (pepper fruit) seed in a rat model of diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664378/
https://www.ncbi.nlm.nih.gov/pubmed/29181401
http://dx.doi.org/10.1155/2017/6923629
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