Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells

Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation. The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem cells. The deregulation of its expression or activ...

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Detalles Bibliográficos
Autores principales: Delestré, Laure, Cui, Hengxiang, Esposito, Michela, Quiveron, Cyril, Mylonas, Elena, Penard-Lacronique, Virginie, Bischof, Oliver, Guillouf, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664389/
https://www.ncbi.nlm.nih.gov/pubmed/28912174
http://dx.doi.org/10.3324/haematol.2016.157636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664389/
https://www.ncbi.nlm.nih.gov/pubmed/28912174
http://dx.doi.org/10.3324/haematol.2016.157636

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