Immune response against rickettsiae: lessons from murine infection models

Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacter...

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Detalles Bibliográficos
Autor principal: Osterloh, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664416/
https://www.ncbi.nlm.nih.gov/pubmed/28770333
http://dx.doi.org/10.1007/s00430-017-0514-1
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author Osterloh, Anke
author_facet Osterloh, Anke
author_sort Osterloh, Anke
collection PubMed
description Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions. This review summarizes the current knowledge about immune mechanisms in protection and pathology in rickettsial infections.
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spelling pubmed-56644162017-11-16 Immune response against rickettsiae: lessons from murine infection models Osterloh, Anke Med Microbiol Immunol Review Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions. This review summarizes the current knowledge about immune mechanisms in protection and pathology in rickettsial infections. Springer Berlin Heidelberg 2017-08-02 2017 /pmc/articles/PMC5664416/ /pubmed/28770333 http://dx.doi.org/10.1007/s00430-017-0514-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Osterloh, Anke
Immune response against rickettsiae: lessons from murine infection models
title Immune response against rickettsiae: lessons from murine infection models
title_full Immune response against rickettsiae: lessons from murine infection models
title_fullStr Immune response against rickettsiae: lessons from murine infection models
title_full_unstemmed Immune response against rickettsiae: lessons from murine infection models
title_short Immune response against rickettsiae: lessons from murine infection models
title_sort immune response against rickettsiae: lessons from murine infection models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664416/
https://www.ncbi.nlm.nih.gov/pubmed/28770333
http://dx.doi.org/10.1007/s00430-017-0514-1
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