Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit from dormancy have never been investigated. Here we identified the full mitochondrial genome in circulating extracellular vesicles (EVs) from patients with hormonal therapy-resistant (HTR) metastatic breast...

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Detalles Bibliográficos
Autores principales: Sansone, Pasquale, Savini, Claudia, Kurelac, Ivana, Chang, Qing, Amato, Laura Benedetta, Strillacci, Antonio, Stepanova, Anna, Iommarini, Luisa, Mastroleo, Chiara, Daly, Laura, Galkin, Alexander, Thakur, Basant Kumar, Soplop, Nadine, Uryu, Kunihiro, Hoshino, Ayuko, Norton, Larry, Bonafé, Massimiliano, Cricca, Monica, Gasparre, Giuseppe, Lyden, David, Bromberg, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664494/
https://www.ncbi.nlm.nih.gov/pubmed/29073103
http://dx.doi.org/10.1073/pnas.1704862114

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