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Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis

Poor initiation and implementation and premature discontinuation of anti-tuberculous therapy, all forms of nonadherence, are major reasons for treatment failure, the development of drug-resistant tuberculosis, and transmission to other non-infected individuals. Directly Observed Therapy (DOT) has be...

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Autores principales: Liu, Xiaoqiu, Blaschke, Terrence, Thomas, Bruce, De Geest, Sabina, Jiang, Shiwen, Gao, Yongxin, Li, Xinxu, Buono, Elizabeth Whalley, Buchanan, Stacy, Zhang, Zhiying, Huan, Shitong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664616/
https://www.ncbi.nlm.nih.gov/pubmed/28946683
http://dx.doi.org/10.3390/ijerph14101115
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author Liu, Xiaoqiu
Blaschke, Terrence
Thomas, Bruce
De Geest, Sabina
Jiang, Shiwen
Gao, Yongxin
Li, Xinxu
Buono, Elizabeth Whalley
Buchanan, Stacy
Zhang, Zhiying
Huan, Shitong
author_facet Liu, Xiaoqiu
Blaschke, Terrence
Thomas, Bruce
De Geest, Sabina
Jiang, Shiwen
Gao, Yongxin
Li, Xinxu
Buono, Elizabeth Whalley
Buchanan, Stacy
Zhang, Zhiying
Huan, Shitong
author_sort Liu, Xiaoqiu
collection PubMed
description Poor initiation and implementation and premature discontinuation of anti-tuberculous therapy, all forms of nonadherence, are major reasons for treatment failure, the development of drug-resistant tuberculosis, and transmission to other non-infected individuals. Directly Observed Therapy (DOT) has been the worldwide standard, but implementation of DOT is burdensome for providers and patients, especially in resource-limited settings, where most of the burden of active TB is located. Among the alternatives to DOT is electronic monitoring (EM) of drug dosing histories. Here we report a usability study of a newly-designed, modular electronic monitor product, called the MERM (Medication Event and Reminder Monitor), that is compatible with TB medication formats and supply chains in resource-limited settings. This study, done in a rural setting in China, showed that the use of the MERM for EM of TB medications was associated with a high degree of user performance, acceptability, and satisfaction among both TB patients and medical staff. Based on these data, EM is becoming the standard of care for drug-susceptible TB patients in China and scaled implementations in several other countries with high TB burden have begun. In addition, the MERM is being used in MDR-TB patients and in clinical trials involving patients with TB/HIV and latent TB.
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spelling pubmed-56646162017-11-06 Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis Liu, Xiaoqiu Blaschke, Terrence Thomas, Bruce De Geest, Sabina Jiang, Shiwen Gao, Yongxin Li, Xinxu Buono, Elizabeth Whalley Buchanan, Stacy Zhang, Zhiying Huan, Shitong Int J Environ Res Public Health Article Poor initiation and implementation and premature discontinuation of anti-tuberculous therapy, all forms of nonadherence, are major reasons for treatment failure, the development of drug-resistant tuberculosis, and transmission to other non-infected individuals. Directly Observed Therapy (DOT) has been the worldwide standard, but implementation of DOT is burdensome for providers and patients, especially in resource-limited settings, where most of the burden of active TB is located. Among the alternatives to DOT is electronic monitoring (EM) of drug dosing histories. Here we report a usability study of a newly-designed, modular electronic monitor product, called the MERM (Medication Event and Reminder Monitor), that is compatible with TB medication formats and supply chains in resource-limited settings. This study, done in a rural setting in China, showed that the use of the MERM for EM of TB medications was associated with a high degree of user performance, acceptability, and satisfaction among both TB patients and medical staff. Based on these data, EM is becoming the standard of care for drug-susceptible TB patients in China and scaled implementations in several other countries with high TB burden have begun. In addition, the MERM is being used in MDR-TB patients and in clinical trials involving patients with TB/HIV and latent TB. MDPI 2017-09-25 2017-10 /pmc/articles/PMC5664616/ /pubmed/28946683 http://dx.doi.org/10.3390/ijerph14101115 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Xiaoqiu
Blaschke, Terrence
Thomas, Bruce
De Geest, Sabina
Jiang, Shiwen
Gao, Yongxin
Li, Xinxu
Buono, Elizabeth Whalley
Buchanan, Stacy
Zhang, Zhiying
Huan, Shitong
Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
title Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
title_full Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
title_fullStr Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
title_full_unstemmed Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
title_short Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
title_sort usability of a medication event reminder monitor system (merm) by providers and patients to improve adherence in the management of tuberculosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664616/
https://www.ncbi.nlm.nih.gov/pubmed/28946683
http://dx.doi.org/10.3390/ijerph14101115
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