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Environmental Risk Assessment Strategy for Nanomaterials

An Environmental Risk Assessment (ERA) for nanomaterials (NMs) is outlined in this paper. Contrary to other recent papers on the subject, the main data requirements, models and advancement within each of the four risk assessment domains are described, i.e., in the: (i) materials, (ii) release, fate...

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Autores principales: Scott-Fordsmand, Janeck J., Peijnenburg, Willie J. G. M., Semenzin, Elena, Nowack, Bernd, Hunt, Neil, Hristozov, Danail, Marcomini, Antonio, Irfan, Muhammad-Adeel, Jiménez, Araceli Sánchez, Landsiedel, Robert, Tran, Lang, Oomen, Agnes G., Bos, Peter M. J., Hund-Rinke, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664752/
https://www.ncbi.nlm.nih.gov/pubmed/29048395
http://dx.doi.org/10.3390/ijerph14101251
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author Scott-Fordsmand, Janeck J.
Peijnenburg, Willie J. G. M.
Semenzin, Elena
Nowack, Bernd
Hunt, Neil
Hristozov, Danail
Marcomini, Antonio
Irfan, Muhammad-Adeel
Jiménez, Araceli Sánchez
Landsiedel, Robert
Tran, Lang
Oomen, Agnes G.
Bos, Peter M. J.
Hund-Rinke, Kerstin
author_facet Scott-Fordsmand, Janeck J.
Peijnenburg, Willie J. G. M.
Semenzin, Elena
Nowack, Bernd
Hunt, Neil
Hristozov, Danail
Marcomini, Antonio
Irfan, Muhammad-Adeel
Jiménez, Araceli Sánchez
Landsiedel, Robert
Tran, Lang
Oomen, Agnes G.
Bos, Peter M. J.
Hund-Rinke, Kerstin
author_sort Scott-Fordsmand, Janeck J.
collection PubMed
description An Environmental Risk Assessment (ERA) for nanomaterials (NMs) is outlined in this paper. Contrary to other recent papers on the subject, the main data requirements, models and advancement within each of the four risk assessment domains are described, i.e., in the: (i) materials, (ii) release, fate and exposure, (iii) hazard and (iv) risk characterisation domains. The material, which is obviously the foundation for any risk assessment, should be described according to the legislatively required characterisation data. Characterisation data will also be used at various levels within the ERA, e.g., exposure modelling. The release, fate and exposure data and models cover the input for environmental distribution models in order to identify the potential (PES) and relevant exposure scenarios (RES) and, subsequently, the possible release routes, both with regard to which compartment(s) NMs are distributed in line with the factors determining the fate within environmental compartment. The initial outcome in the risk characterisation will be a generic Predicted Environmental Concentration (PEC), but a refined PEC can be obtained by applying specific exposure models for relevant media. The hazard information covers a variety of representative, relevant and reliable organisms and/or functions, relevant for the RES and enabling a hazard characterisation. The initial outcome will be hazard characterisation in test systems allowing estimating a Predicted No-Effect concentration (PNEC), either based on uncertainty factors or on a NM adapted version of the Species Sensitivity Distributions approach. The risk characterisation will either be based on a deterministic risk ratio approach (i.e., PEC/PNEC) or an overlay of probability distributions, i.e., exposure and hazard distributions, using the nano relevant models.
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spelling pubmed-56647522017-11-06 Environmental Risk Assessment Strategy for Nanomaterials Scott-Fordsmand, Janeck J. Peijnenburg, Willie J. G. M. Semenzin, Elena Nowack, Bernd Hunt, Neil Hristozov, Danail Marcomini, Antonio Irfan, Muhammad-Adeel Jiménez, Araceli Sánchez Landsiedel, Robert Tran, Lang Oomen, Agnes G. Bos, Peter M. J. Hund-Rinke, Kerstin Int J Environ Res Public Health Article An Environmental Risk Assessment (ERA) for nanomaterials (NMs) is outlined in this paper. Contrary to other recent papers on the subject, the main data requirements, models and advancement within each of the four risk assessment domains are described, i.e., in the: (i) materials, (ii) release, fate and exposure, (iii) hazard and (iv) risk characterisation domains. The material, which is obviously the foundation for any risk assessment, should be described according to the legislatively required characterisation data. Characterisation data will also be used at various levels within the ERA, e.g., exposure modelling. The release, fate and exposure data and models cover the input for environmental distribution models in order to identify the potential (PES) and relevant exposure scenarios (RES) and, subsequently, the possible release routes, both with regard to which compartment(s) NMs are distributed in line with the factors determining the fate within environmental compartment. The initial outcome in the risk characterisation will be a generic Predicted Environmental Concentration (PEC), but a refined PEC can be obtained by applying specific exposure models for relevant media. The hazard information covers a variety of representative, relevant and reliable organisms and/or functions, relevant for the RES and enabling a hazard characterisation. The initial outcome will be hazard characterisation in test systems allowing estimating a Predicted No-Effect concentration (PNEC), either based on uncertainty factors or on a NM adapted version of the Species Sensitivity Distributions approach. The risk characterisation will either be based on a deterministic risk ratio approach (i.e., PEC/PNEC) or an overlay of probability distributions, i.e., exposure and hazard distributions, using the nano relevant models. MDPI 2017-10-19 2017-10 /pmc/articles/PMC5664752/ /pubmed/29048395 http://dx.doi.org/10.3390/ijerph14101251 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scott-Fordsmand, Janeck J.
Peijnenburg, Willie J. G. M.
Semenzin, Elena
Nowack, Bernd
Hunt, Neil
Hristozov, Danail
Marcomini, Antonio
Irfan, Muhammad-Adeel
Jiménez, Araceli Sánchez
Landsiedel, Robert
Tran, Lang
Oomen, Agnes G.
Bos, Peter M. J.
Hund-Rinke, Kerstin
Environmental Risk Assessment Strategy for Nanomaterials
title Environmental Risk Assessment Strategy for Nanomaterials
title_full Environmental Risk Assessment Strategy for Nanomaterials
title_fullStr Environmental Risk Assessment Strategy for Nanomaterials
title_full_unstemmed Environmental Risk Assessment Strategy for Nanomaterials
title_short Environmental Risk Assessment Strategy for Nanomaterials
title_sort environmental risk assessment strategy for nanomaterials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664752/
https://www.ncbi.nlm.nih.gov/pubmed/29048395
http://dx.doi.org/10.3390/ijerph14101251
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