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Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population

BACKGROUND: Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to...

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Autores principales: Yamaguchi, Natsu, Mahbub, MH, Takahashi, Hidekazu, Hase, Ryosuke, Ishimaru, Yasutaka, Sunagawa, Hiroshi, Amano, Hiroki, Kobayashi- Miura, Mikiko, Kanda, Hideyuki, Fujita, Yasuyuki, Yamamoto, Hiroshi, Yamamoto, Mai, Kikuchi, Shinya, Ikeda, Atsuko, Takasu, Mariko, Kageyama, Naoko, Nakamura, Mina, Tanabe, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664911/
https://www.ncbi.nlm.nih.gov/pubmed/29165132
http://dx.doi.org/10.1186/s12199-017-0642-7
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author Yamaguchi, Natsu
Mahbub, MH
Takahashi, Hidekazu
Hase, Ryosuke
Ishimaru, Yasutaka
Sunagawa, Hiroshi
Amano, Hiroki
Kobayashi- Miura, Mikiko
Kanda, Hideyuki
Fujita, Yasuyuki
Yamamoto, Hiroshi
Yamamoto, Mai
Kikuchi, Shinya
Ikeda, Atsuko
Takasu, Mariko
Kageyama, Naoko
Nakamura, Mina
Tanabe, Tsuyoshi
author_facet Yamaguchi, Natsu
Mahbub, MH
Takahashi, Hidekazu
Hase, Ryosuke
Ishimaru, Yasutaka
Sunagawa, Hiroshi
Amano, Hiroki
Kobayashi- Miura, Mikiko
Kanda, Hideyuki
Fujita, Yasuyuki
Yamamoto, Hiroshi
Yamamoto, Mai
Kikuchi, Shinya
Ikeda, Atsuko
Takasu, Mariko
Kageyama, Naoko
Nakamura, Mina
Tanabe, Tsuyoshi
author_sort Yamaguchi, Natsu
collection PubMed
description BACKGROUND: Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population. METHODS: We examined plasma concentrations of 19 amino acids in 8589 Japanese subjects, and determined the association with variables associated with obesity, blood glucose, lipid, and blood pressure. We also evaluated the PFAA indexes that reflect visceral fat obesity and insulin resistance. The contribution of single PFAA level and relevant PFAA indexes was also examined in the risk assessment of lifestyle-related diseases. RESULTS: Of the 19 amino acids, branched-chain amino acids and aromatic amino acids showed association with obesity and lipid variables. The PFAA index related to visceral fat obesity showed relatively higher correlation with variables than that of any PFAA. In the evaluation of lifestyle-related disease risks, the odds ratios of the PFAA index related to visceral fat obesity or insulin resistance with the diseases were higher than most of those of individual amino acid levels even after adjusting for potential confounding factors. The association pattern of the indexes and PFAA with each lifestyle-related disease was distinct. CONCLUSIONS: We confirmed the usefulness of PFAA profiles and indexes as markers for evaluating the risks of lifestyle-related diseases, including diabetes mellitus, metabolic syndrome, dyslipidemia, and hypertension in a large Asian population.
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spelling pubmed-56649112017-11-08 Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population Yamaguchi, Natsu Mahbub, MH Takahashi, Hidekazu Hase, Ryosuke Ishimaru, Yasutaka Sunagawa, Hiroshi Amano, Hiroki Kobayashi- Miura, Mikiko Kanda, Hideyuki Fujita, Yasuyuki Yamamoto, Hiroshi Yamamoto, Mai Kikuchi, Shinya Ikeda, Atsuko Takasu, Mariko Kageyama, Naoko Nakamura, Mina Tanabe, Tsuyoshi Environ Health Prev Med Research Article BACKGROUND: Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population. METHODS: We examined plasma concentrations of 19 amino acids in 8589 Japanese subjects, and determined the association with variables associated with obesity, blood glucose, lipid, and blood pressure. We also evaluated the PFAA indexes that reflect visceral fat obesity and insulin resistance. The contribution of single PFAA level and relevant PFAA indexes was also examined in the risk assessment of lifestyle-related diseases. RESULTS: Of the 19 amino acids, branched-chain amino acids and aromatic amino acids showed association with obesity and lipid variables. The PFAA index related to visceral fat obesity showed relatively higher correlation with variables than that of any PFAA. In the evaluation of lifestyle-related disease risks, the odds ratios of the PFAA index related to visceral fat obesity or insulin resistance with the diseases were higher than most of those of individual amino acid levels even after adjusting for potential confounding factors. The association pattern of the indexes and PFAA with each lifestyle-related disease was distinct. CONCLUSIONS: We confirmed the usefulness of PFAA profiles and indexes as markers for evaluating the risks of lifestyle-related diseases, including diabetes mellitus, metabolic syndrome, dyslipidemia, and hypertension in a large Asian population. BioMed Central 2017-04-07 2017 /pmc/articles/PMC5664911/ /pubmed/29165132 http://dx.doi.org/10.1186/s12199-017-0642-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yamaguchi, Natsu
Mahbub, MH
Takahashi, Hidekazu
Hase, Ryosuke
Ishimaru, Yasutaka
Sunagawa, Hiroshi
Amano, Hiroki
Kobayashi- Miura, Mikiko
Kanda, Hideyuki
Fujita, Yasuyuki
Yamamoto, Hiroshi
Yamamoto, Mai
Kikuchi, Shinya
Ikeda, Atsuko
Takasu, Mariko
Kageyama, Naoko
Nakamura, Mina
Tanabe, Tsuyoshi
Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population
title Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population
title_full Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population
title_fullStr Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population
title_full_unstemmed Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population
title_short Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population
title_sort plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large asian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664911/
https://www.ncbi.nlm.nih.gov/pubmed/29165132
http://dx.doi.org/10.1186/s12199-017-0642-7
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