Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma

Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI chromosomal translocation. The resulting fusion protein is an aberrant transcription factor that uses highly repetitive GGAA-containing elements (microsatellites) to activate and repress thousands of ta...

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Detalles Bibliográficos
Autores principales: Johnson, Kirsten M., Taslim, Cenny, Saund, Ranajeet S., Lessnick, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665490/
https://www.ncbi.nlm.nih.gov/pubmed/29091716
http://dx.doi.org/10.1371/journal.pone.0186275

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