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IL-23 signaling in Th17 cells is inhibited by HIV infection and is not restored by HAART: Implications for persistent immune activation

OBJECTIVES: HIV infection causes a profound depletion of gut derived Th17 cells, contributing to loss of mucosal barrier function and an increase in microbial translocation, thus driving systemic immune activation. Despite normalization of circulating CD4+ T cell counts with highly active antiretrov...

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Detalles Bibliográficos
Autores principales:	Fernandes, Jason R., Berthoud, Tamara K., Kumar, Ashok, Angel, Jonathan B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665519/ https://www.ncbi.nlm.nih.gov/pubmed/29091911 http://dx.doi.org/10.1371/journal.pone.0186823

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