Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion

Incretins (GLP-1 and GIP) potentiate insulin secretion through cAMP signaling in pancreatic β-cells in a glucose-dependent manner. We recently proposed a mechanistic model of incretin-induced insulin secretion (IIIS) that requires two critical processes: 1) generation of cytosolic glutamate through...

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Detalles Bibliográficos
Autores principales: Murao, Naoya, Yokoi, Norihide, Honda, Kohei, Han, Guirong, Hayami, Tomohide, Gheni, Ghupurjan, Takahashi, Harumi, Minami, Kohtaro, Seino, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665537/
https://www.ncbi.nlm.nih.gov/pubmed/29091932
http://dx.doi.org/10.1371/journal.pone.0187213

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