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A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations

Research on the mechanism of post stroke depression (PSD) is the key way to improve the treatment of PSD. However, the functional brain network of PSD has not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study are to investigate the...

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Autores principales: Shi, Yu, Zeng, Yanyan, Wu, Lei, Liu, Ziping, Zhang, Shanshan, Yang, Jianming, Wu, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665859/
https://www.ncbi.nlm.nih.gov/pubmed/29093543
http://dx.doi.org/10.1038/s41598-017-14675-4
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author Shi, Yu
Zeng, Yanyan
Wu, Lei
Liu, Ziping
Zhang, Shanshan
Yang, Jianming
Wu, Wen
author_facet Shi, Yu
Zeng, Yanyan
Wu, Lei
Liu, Ziping
Zhang, Shanshan
Yang, Jianming
Wu, Wen
author_sort Shi, Yu
collection PubMed
description Research on the mechanism of post stroke depression (PSD) is the key way to improve the treatment of PSD. However, the functional brain network of PSD has not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study are to investigate the brain response of PSD in three different lesions. The brain responses of the three PSD subgroups were similar. However, each subgroup had its own characteristics of the brain network. In the temporal lobe subgroup, the right thalamus had increased degree centrality (DC) values which were different from the other two subgroups. In the frontal lobe subgroup, the left dorsolateral prefrontal cortex, caudate, and postcentral gyrus had increased DC values which were different from the other two subgroups. The hemodynamic response of PSD indicates that PSD has activities of similar emotional networks, of which the negative network realizes its function through the limbic system and default mode network. The brain network has unique characteristics for different lesion locations. The neurological function of the lesion location, the compensatory mechanism of the brain, and the mechanism of integrity and locality of the brain are the important factors in the individual emotional network.
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spelling pubmed-56658592017-11-08 A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations Shi, Yu Zeng, Yanyan Wu, Lei Liu, Ziping Zhang, Shanshan Yang, Jianming Wu, Wen Sci Rep Article Research on the mechanism of post stroke depression (PSD) is the key way to improve the treatment of PSD. However, the functional brain network of PSD has not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study are to investigate the brain response of PSD in three different lesions. The brain responses of the three PSD subgroups were similar. However, each subgroup had its own characteristics of the brain network. In the temporal lobe subgroup, the right thalamus had increased degree centrality (DC) values which were different from the other two subgroups. In the frontal lobe subgroup, the left dorsolateral prefrontal cortex, caudate, and postcentral gyrus had increased DC values which were different from the other two subgroups. The hemodynamic response of PSD indicates that PSD has activities of similar emotional networks, of which the negative network realizes its function through the limbic system and default mode network. The brain network has unique characteristics for different lesion locations. The neurological function of the lesion location, the compensatory mechanism of the brain, and the mechanism of integrity and locality of the brain are the important factors in the individual emotional network. Nature Publishing Group UK 2017-11-01 /pmc/articles/PMC5665859/ /pubmed/29093543 http://dx.doi.org/10.1038/s41598-017-14675-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shi, Yu
Zeng, Yanyan
Wu, Lei
Liu, Ziping
Zhang, Shanshan
Yang, Jianming
Wu, Wen
A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations
title A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations
title_full A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations
title_fullStr A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations
title_full_unstemmed A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations
title_short A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations
title_sort study of the brain functional network of post-stroke depression in three different lesion locations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665859/
https://www.ncbi.nlm.nih.gov/pubmed/29093543
http://dx.doi.org/10.1038/s41598-017-14675-4
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