Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice

Disruption of insulin secretion and clearance both contribute to obesity-induced hyperinsulinemia, though reduced insulin clearance seems to be the main factor. The liver is the major site for insulin degradation, a process mainly coordinated by the insulin-degrading enzyme (IDE). The beneficial eff...

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Detalles Bibliográficos
Autores principales: Vettorazzi, Jean Franciesco, Kurauti, Mirian Ayumi, Soares, Gabriela Moreira, Borck, Patricia Cristine, Ferreira, Sandra Mara, Branco, Renato Chaves Souto, Michelone, Luciana de Souza Lima, Boschero, Antonio Carlos, Junior, Jose Maria Costa, Carneiro, Everardo Magalhães
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665899/
https://www.ncbi.nlm.nih.gov/pubmed/29093479
http://dx.doi.org/10.1038/s41598-017-13974-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665899/
https://www.ncbi.nlm.nih.gov/pubmed/29093479
http://dx.doi.org/10.1038/s41598-017-13974-0

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