Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

Dilated cardiomyopathy (DCM) is an important cause of heart failure. Single gene mutations in at least 50 genes have been proposed to account for 25–50% of DCM cases and up to 25% of inherited DCM has been attributed to truncating mutations in the sarcomeric structural protein titin (TTNtv). Whilst...

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Detalles Bibliográficos
Autores principales: Vikhorev, Petr G., Smoktunowicz, Natalia, Munster, Alex B., Copeland, O’Neal, Kostin, Sawa, Montgiraud, Cecile, Messer, Andrew E., Toliat, Mohammad R., Li, Amy, dos Remedios, Cristobal G., Lal, Sean, Blair, Cheavar A., Campbell, Kenneth S., Guglin, Maya, Richter, Manfred, Knöll, Ralph, Marston, Steven B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665940/
https://www.ncbi.nlm.nih.gov/pubmed/29093449
http://dx.doi.org/10.1038/s41598-017-13675-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665940/
https://www.ncbi.nlm.nih.gov/pubmed/29093449
http://dx.doi.org/10.1038/s41598-017-13675-8

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