HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

The human protease family HtrA is responsible for preventing protein misfolding and mislocalization, and a key player in several cellular processes. Among these, HtrA1 is implicated in several cancers, cerebrovascular disease and age-related macular degeneration. Currently, HtrA1 activation is not f...

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Detalles Bibliográficos
Autores principales: Cabrera, Alvaro Cortes, Melo, Esther, Roth, Doris, Topp, Andreas, Delobel, Frederic, Stucki, Corinne, Chen, Chia-yi, Jakob, Peter, Banfai, Balazs, Dunkley, Tom, Schilling, Oliver, Huber, Sylwia, Iacone, Roberto, Petrone, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666011/
https://www.ncbi.nlm.nih.gov/pubmed/29093542
http://dx.doi.org/10.1038/s41598-017-14208-z

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