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Persistent detection of alternatively spliced BCR‐ABL variant results in a failure to achieve deep molecular response

Treatment with tyrosine kinase inhibitors (TKI) may sequentially induce TKI‐resistant BCR‐ABL mutants in chronic myeloid leukemia (CML). Conventional PCR monitoring of BCR‐ABL is an important indicator to determine therapeutic intervention for preventing disease progression. However, PCR cannot sepa...

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Detalles Bibliográficos
Autores principales:	Yuda, Junichiro, Miyamoto, Toshihiro, Odawara, Jun, Ohkawa, Yasuyuki, Semba, Yuichiro, Hayashi, Masayasu, Miyamura, Koichi, Tanimoto, Mitsune, Yamamoto, Kazuhito, Taniwaki, Masafumi, Akashi, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666036/ https://www.ncbi.nlm.nih.gov/pubmed/28801986 http://dx.doi.org/10.1111/cas.13353

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