Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome sequencing t...

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Detalles Bibliográficos
Autores principales: Jorth, Peter, McLean, Kathryn, Ratjen, Anina, Secor, Patrick R., Bautista, Gilbert E., Ravishankar, Sumedha, Rezayat, Amir, Garudathri, Jayanthi, Harrison, Joe J., Harwood, Rachel A., Penewit, Kelsi, Waalkes, Adam, Singh, Pradeep K., Salipante, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666152/
https://www.ncbi.nlm.nih.gov/pubmed/29089424
http://dx.doi.org/10.1128/mBio.00517-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666152/
https://www.ncbi.nlm.nih.gov/pubmed/29089424
http://dx.doi.org/10.1128/mBio.00517-17

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