Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that inactivate “last-line” antibiotics such as imipenem, represents a major challenge to contemporary antibiotic therapies. The combination of ceftazidime (CAZ) and avibactam (AVI), a potent β-lactamase inhibitor, represents...

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Detalles Bibliográficos
Autores principales: Barnes, Melissa D., Winkler, Marisa L., Taracila, Magdalena A., Page, Malcolm G., Desarbre, Eric, Kreiswirth, Barry N., Shields, Ryan K., Nguyen, Minh-Hong, Clancy, Cornelius, Spellberg, Brad, Papp-Wallace, Krisztina M., Bonomo, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666153/
https://www.ncbi.nlm.nih.gov/pubmed/29089425
http://dx.doi.org/10.1128/mBio.00528-17

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