An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia

Leukemias harboring the ETV6-ABL1 fusion represent a rare subset of hematological malignancies with unfavorable outcomes. The constitutively active chimeric Etv6-Abl1 tyrosine kinase can be specifically inhibited by tyrosine kinase inhibitors (TKIs). Although TKIs represent an important therapeutic...

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Detalles Bibliográficos
Autores principales: Zimmermannova, O, Doktorova, E, Stuchly, J, Kanderova, V, Kuzilkova, D, Strnad, H, Starkova, J, Alberich-Jorda, M, Falkenburg, J H F, Trka, J, Petrak, J, Zuna, J, Zaliova, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666322/
https://www.ncbi.nlm.nih.gov/pubmed/28650474
http://dx.doi.org/10.1038/onc.2017.210

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