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In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking

Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific m...

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Autores principales: Mandal, Chanchal, Halder, Debasish, Jung, Kyoung Hwa, Chai, Young Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666325/
https://www.ncbi.nlm.nih.gov/pubmed/29104501
http://dx.doi.org/10.7150/ijbs.21047
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author Mandal, Chanchal
Halder, Debasish
Jung, Kyoung Hwa
Chai, Young Gyu
author_facet Mandal, Chanchal
Halder, Debasish
Jung, Kyoung Hwa
Chai, Young Gyu
author_sort Mandal, Chanchal
collection PubMed
description Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific mechanism of action behind this teratogenic effect is still unknown. Previous reports demonstrated that alcohol participates in epigenetic alterations, especially histone modifications during fetal development. Additional research is necessary to understand the correlation between major epigenetic events and alcohol-mediated teratogenesis such as that observed in fetal alcohol spectrum disorder (FASD). Here, we attempted to collect all the available information concerning alcohol-mediated histone modifications during gestational fetal development. We hope that this review will aid researchers to further examine the issues associated with ethanol exposure.
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spelling pubmed-56663252017-11-04 In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking Mandal, Chanchal Halder, Debasish Jung, Kyoung Hwa Chai, Young Gyu Int J Biol Sci Review Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific mechanism of action behind this teratogenic effect is still unknown. Previous reports demonstrated that alcohol participates in epigenetic alterations, especially histone modifications during fetal development. Additional research is necessary to understand the correlation between major epigenetic events and alcohol-mediated teratogenesis such as that observed in fetal alcohol spectrum disorder (FASD). Here, we attempted to collect all the available information concerning alcohol-mediated histone modifications during gestational fetal development. We hope that this review will aid researchers to further examine the issues associated with ethanol exposure. Ivyspring International Publisher 2017-09-05 /pmc/articles/PMC5666325/ /pubmed/29104501 http://dx.doi.org/10.7150/ijbs.21047 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Mandal, Chanchal
Halder, Debasish
Jung, Kyoung Hwa
Chai, Young Gyu
In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
title In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
title_full In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
title_fullStr In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
title_full_unstemmed In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
title_short In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
title_sort in utero alcohol exposure and the alteration of histone marks in the developing fetus: an epigenetic phenomenon of maternal drinking
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666325/
https://www.ncbi.nlm.nih.gov/pubmed/29104501
http://dx.doi.org/10.7150/ijbs.21047
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