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P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes

The pore forming hemolysin A, Hla, is a major virulence factor of Staphylococcus aureus. Apparently, 1–2 pore(s) per cell suffice(s) to cause cell death. Accumulated experimental evidence points towards a major role of ATP-gated purinergic receptors (P2XR) for hemolysis caused by Hla, complement and...

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Detalles Bibliográficos
Autores principales:	Schwiering, Markus, Husmann, Matthias, Hellmann, Nadja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666378/ https://www.ncbi.nlm.nih.gov/pubmed/29048353 http://dx.doi.org/10.3390/toxins9100332

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